Evidence map›Paper›PMID 40696042›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

The evolution of tremor in Parkinson's Disease: insights from a 4-year longitudinal assessment.

Carolina Cutrona, Matteo Costanzo, Giorgio Leodori, Maria Ilenia De Bartolo, Agnese Liguori, Francesco Marchet, Marco Mancuso, Giorgio Vivacqua, Antonella Conte, Giovanni Fabbrini and 2 more

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Temporal Dynamics of Parkinson's Disease Tremor: Clinical and Neuroimaging Insights.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  2. Letter to the Editor regarding "The effects of transcranial magnetic stimulation in motor symptoms of Parkinson's disease: an overview of systematic reviews with meta-analysis".Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carolina Cutrona *Department of Human Neuroscience, Sapienza University of Rome, Viale Dell'Università 30, Rome, 00185, Italy.
Matteo Costanzo *Department of Human Neuroscience, Sapienza University of Rome, Viale Dell'Università 30, Rome, 00185, Italy.
Giorgio LeodoriDepartment of Human Neuroscience, Sapienza University of Rome, Viale Dell'Università 30, Rome, 00185, Italy.
Maria Ilenia De BartoloIRCCS Neuromed, Via Atinense 18, Pozzilli, IS, 86077, Italy.
Agnese LiguoriDepartment of Neurology, Ruggi D'Aragona and S.Giovanni Di Dio Hospital, Via San Leonardo, Salerno, 84131, Italy.
Francesco MarchetDepartment of Human Neuroscience, Sapienza University of Rome, Viale Dell'Università 30, Rome, 00185, Italy.
Marco MancusoDepartment of Human Neuroscience, Sapienza University of Rome, Viale Dell'Università 30, Rome, 00185, Italy.
Giorgio VivacquaDepartment of Experimental Morphology and Microscopy- Integrated Research Center (PRAAB), Biomedico University of Rome, Via A. del Portillo 21, Rome, 00125, Italy.
Antonella ConteDepartment of Human Neuroscience, Sapienza University of Rome, Viale Dell'Università 30, Rome, 00185, Italy.
Giovanni FabbriniDepartment of Human Neuroscience, Sapienza University of Rome, Viale Dell'Università 30, Rome, 00185, Italy.
Alfredo BerardelliIRCCS Neuromed, Via Atinense 18, Pozzilli, IS, 86077, Italy.
Daniele BelvisiDepartment of Human Neuroscience, Sapienza University of Rome, Viale Dell'Università 30, Rome, 00185, Italy. daniele.belvisi@uniroma1.it.ORCID http://orcid.org/0000-0001-8681-3050

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWhile tremor is considered a cardinal motor sign in patients with Parkinson's disease (PD), little is known about the evolution of the different types of PD tremor over time.

aimsOur objectives were to assess the rate of progression of the various types of PD tremor over the disease course and to verify if the presence of different tremors is consistently associated with specific motor and non-motor burdens over time. Finally, we investigated whether the presence of different tremors can predict specific trajectories of disease progression.

methodsOne hundred PD patients were enrolled and 73 completed a 4-year follow up. Clinical evaluations included the administration of standardized PD scales to assess the severity of motor and non-motor manifestations. The occurrence and severity of rest, re-emergent, and action tremors were accurately evaluated at baseline and 4 years later. Adjusted linear regression models were used to assess tremor type's influence on disease progression.

resultsTremor occurrence and severity decreased during PD progression, with a more significant reduction in action tremor compared to rest and re-emergent tremor. Patients with rest and re-emergent tremor had milder motor symptoms at baseline and milder motor and non-motor manifestations at follow-up. The presence of rest and re-emergent tremor predicted a lower progression of non-motor symptoms.

conclusionsThis longitudinal study revealed that the various types of PD tremor have different evolutions over disease course, can predict distinct trajectories of disease progression and are underpinned by distinct pathophysiological mechanisms.

Indexed as

Disease ProgressionParkinson DiseaseTremorAgedFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedSeverity of Illness IndexAction tremorClinical courseLongitudinal studiesParkinson’s diseaseResting tremorTremor

Identifiers

PMID40696042
PMCPMC12394333

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.