ArticleScientific reports2025
Shiga toxin-producing Escherichia coli plasmid diversity reveals virulence potential and control opportunities in animal hosts.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Comprehensive Genomic Analysis of the pO157 Plasmid in Enterohemorrhagic Escherichia coli O157:H7 Reveals Non-synonymous Variation in Virulence Factors.Current microbiology · 2026Article
- Integrative Modular, Network-Based, and Machine Learning Framework for Predicting Accessory Genome Functions and Virulence in Escherichia coli O157:H7.MicrobiologyOpen · 2026Article
- Serogroups, antibiotic resistance profiles and virulence factors of non-O157 Shiga-toxin producing Escherichia coli from ovine and caprine.Scientific reports · 2026Article
- Dietary Pistachio Skin Effects on Antibiotic-Free Lamb: Virulence Traits, Antimicrobial Resistance, and Clonal Relatedness in CommensalAntibiotics (Basel, Switzerland) · 2026Article
- Global population structure of Shiga toxin-producingMicrobial genomics · 2026Article
- Climate-driven co-evolution of antimicrobial resistance and virulence in Escherichia coli on dairy farms: unraveling adaptive genetic signatures with novel SSCP-PCR.World journal of microbiology & biotechnology · 2025Article
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Authors and funding
4 authors.
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Abstract
Shiga toxin-producing Escherichia coli (STEC) is a significant public health concern, with plasmids playing a key role in its pathogenicity. This study investigates the relationship between plasmid types, virulence genes, and host specificity in 96 STEC strains isolated from cattle, sheep, goats, and pigeons in Iran. We examined the distribution of plasmid-encoded virulence genes, including astA, cma, cba, rhsA1, rhsA2, rhsC, stcE, katP, toxB, espP, subAB, ihaG, LAA iha, saa, etpD, cif, and epeA, along with ehxA subtypes and plasmid replicon types using PCR and RFLP analysis. The most frequently detected virulence factors, rhsC and ihaG, were associated with ehxA subtype A and IncFIB/IncK/B plasmids. Pigeon-derived isolates had a unique virulence profile, including cif but lacking ehxA, suggesting distinct pathogenic mechanisms. stcE and etpD were exclusive to positive controls O157 isolates, linked to ehxA subtype B and IncFIB plasmids. The predominance of ehxA subtype A in ruminants highlights potential host-specific associations. The widespread presence of IncFIB plasmids suggests their broad role in STEC pathogenicity. These findings highlight the critical role of plasmid-encoded virulence factors in STEC pathogenesis and underscore the need for targeted surveillance and control strategies tailored to specific host populations.
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