ArticleCommunications biology2025
Analysis of histone modification interplay reveals two distinct domains in facultative heterochromatin in Pyricularia oryzae.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
Abstract
Histone post-translational modifications (PTMs) interact in complex ways to regulate chromatin structure and gene expression. To investigate this interplay, we analyze ChIP-seq and RNA-seq data from knock-out mutants lacking enzymes responsible for H3K4me2/3, H3K9me3, or H3K27me3 in the phytopathogenic fungus Pyricularia oryzae. Loss of specific PTMs alters other PTMs and gene expression in a compartment-specific manner, with distinct effects across H3K4me2-rich euchromatin (EC), H3K27me3-rich facultative heterochromatin (fHC), H3K9me3-rich constitutive heterochromatin (cHC), and centromeres. We identify two distinct fHC subcompartments: K4-fHC, adjacent to EC, and K9-fHC, adjacent to cHC. Both contain poorly conserved genes, but K9-fHC harbors more transposable elements, while K4-fHC is more enriched for genes upregulated during infection, including effector-like genes. H3K27me3 levels in K4-fHC respond to changes in other PTMs, especially H3K9me3, and to environmental conditions. These findings suggest that K4-fHC functions as a reservoir of genes highly responsive to chromatin context and environmental cues.
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