Evidence map›Paper›PMID 40695960›Full record

ArticleScientific reports2025

Large-sized polystyrene microplastics induce oxidative stress in AML12 cells.

Bitian Zhao, Rui Liu, Shuhao Guo, Shiyu Li, Zekai Huang, Yihan Wang, Cuiping Yu, Zhijun Hou, Yuanyuan Zhang, Yanlong Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bitian ZhaoCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Rui LiuCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Shuhao GuoCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Shiyu LiCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Zekai HuangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Yihan WangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Cuiping YuCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Zhijun HouCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China.
Yuanyuan ZhangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China. yuanyuan85945@126.com.
Yanlong ZhangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China. zhangynlng68@hotmail.com.
Xuedong LiuCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, China. liuxuedong89@126.com.

Funding

Basic Research Expenses for Central Government Department-affiliated Universities 2572022BE03
6 · The paper itself

Abstract

Microplastics (MPs), particularly those exceeding 20 μm in diameter, are increasingly detected in environment and animal tissues, yet their cytotoxicity remains poorly understood. While existing studies focused on MPs with relatively small sizes (≤ 20 μm) or nanoplastics (NPs), the biological impacts of large-sized MPs and amino-modified MPs are underexplored. In this study, we investigated the oxidative stress (OS)-mediated responses of alpha mouse liver 12 (AML12) cells to 50 μm polystyrene MPs (PS-MPs) and polystyrene-amine modified MPs (PS-NH

Indexed as

MicroplasticsOxidative StressPolystyrenesAnimalsApoptosisCell LineCell SurvivalFerroptosisMiceParticle SizeReactive Oxygen SpeciesMicroplasticsPolystyrenesReactive Oxygen SpeciesApoptosisFerroptosisLarge-sized microplasticsOxidative stressPolystyrene

Identifiers

PMID40695960
PMCPMC12284158

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.