Evidence map›Paper›PMID 40695906›Full record

ArticleScientific reports2025

Associations between epigenetic age and brain age in young people.

Faye Sanders, Vilte Baltramonaityte, Gary Donohoe, Neil M Davies, Erin C Dunn, Charlotte A M Cecil, Esther Walton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Faye SandersDepartment of Psychology, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Vilte BaltramonaityteDepartment of Psychology, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Gary DonohoeSchool of Psychology, University of Galway, Galway, Ireland.
Neil M DaviesDivision of Psychiatry, University College London, London, UK.
Erin C DunnDepartment of Sociology, College of Liberal Arts, Purdue University, West Lafayette, IN, USA.
Charlotte A M CecilDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Esther WaltonDepartment of Psychology, University of Bath, Claverton Down, Bath, BA2 7AY, UK. E.Walton@bath.ac.uk.

Funding

European Union's Horizon 2020 research and innovation programme 848158, EarlyCauseEuropean Union's Horizon 2020 Research and Innovation Programme 101039672, TEMPONational Institute of Mental Health of the National Institutes of Health R01MH113930UK Research and Innovation (UKRI) under the UK government's Horizon Europe / ERC Frontier Research Guarantee BrainHealth, grant number EP/Y015037/1
6 · The paper itself

Abstract

Recent research suggests biological age, based on epigenetic or neuroimaging measures, may predict health traits in adulthood more accurately than chronological age. However, it is unclear if these findings apply earlier in life. We aimed to characterise the performance and interdependence between measures of biological age in young people, leveraging a longitudinal subsample from the population-based ALSPAC cohort (n = 386). We derived four epigenetic age measures from blood samples in young people (17-19 years) and a measure of brain age derived from structural neuroimaging data (18-24 years). We examined associations between measures of biological age, and relationships with five measures of physical, cognitive and mental health (8-18 years). We found little evidence for an association between brain age and epigenetic age measures, after accounting for age, sex, cell type, array and study (beta range: -0.59 to 0.59, all p > 0.05). Increased smoking

Indexed as

AgingBrainEpigenesis, GeneticAdolescentAdultChildCognitionDNA MethylationFemaleHumansLongitudinal StudiesMaleNeuroimagingYoung AdultAdolescenceALSPACBrain ageDevelopmentDNA methylationEpigenetic age

Identifiers

PMID40695906
PMCPMC12284137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.