ArticleScientific reports2025
Implications of gene expression heterogeneity in the interplay between acquired resistance and bacterial metabolism.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Diversity and function of OXA-48-like β-lactamase variants in environmentalApplied and environmental microbiology · 2026Article
- Extended-Spectrum Beta-Lactamase (ESBL)-Producing E. coli in Livestock and Free-Roaming Wildlife: A Combined Phenotyping-Whole-Genome Sequencing One Health Approach.Transboundary and emerging diseases · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
Gene expression heterogeneity has an impact on human bacterial pathogens responses, including antimicrobial resistance genes expression. Promoter region variability in resistance genes may include different regulatory boxes involved in metabolic processes essential for bacterial survival. In this study, a molecular tool was developed to characterize promoter region variability and resistance gene expression. For these, 46 bacterial clinical isolates were used. Sequence analysis of resistance genes promoter region showed the existence of different variants for each promoter and identified gene-specific regulatory boxes. Using a fluorescent transcriptional reporter, we analysed the most common promoter variants of the most prevalent acquired resistance genes in clinical isolates (qnrA, qnrB, bla
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