Trial reportScientific reports2025
Effects of high-definition transcranial direct current stimulation for the treatment of chronic insomnia: a randomized, double-blind, controlled trial.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Transcranial direct current stimulation improves reduced global BOLD-CSF coupling in patients with insomnia disorder and comorbid anxiety: a resting-state functional MRI study.BMC psychiatry · 2026Trial
- From Therapeutic Heterogeneity to Precision Neuromodulation: Non-Invasive Brain Stimulation for Chronic Insomnia.Nature and science of sleep · 2026Review
- Bridging mental health, cognition and the brain in mild traumatic brain injury: A multilayer network analysis of the TRACK-TBI study.NeuroImage. Clinical · 2026Article
- Transcranial Direct Current Stimulation (tDCS) in Diabetes: A Focused and Mechanistic Review of Symptom and Function Outcomes.Journal of clinical medicine · 2025Review
- Sleep and sleep disorders: much more than how long you sleep, what truly matters is How you sleep.Scientific reports · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
To evaluate effects of 10-day high-definition transcranial direct current stimulation (HD-tDCS) over the dorsal medial prefrontal cortex (DMPFC) in patients with chronic insomnia. Fifty-five chronic insomnia patients were randomized into two groups: an active tDCS group received 10 days of active anode HD-tDCS stimulation, and a sham tDCS group received sham stimulation. A anode stimulation electrode was placed in Fz (10/20 system) which intend to target the bilateral hemisphere DMPFC, and four cathodes were placed at FPz, F3, Cz, and F4 (10/20 system). We performed polysomnography (PSG) and self-reported sleep scale evaluations before and after the stimulation sessions. Compared with the sham tDCS group, the active tDCS group showed decreases in Pittsburgh Sleep Quality Index (PSQI) scores. In exploratory studies, sleep onset latency (SOL) and sleep efficiency (SE) measured by PSG improved after treatment. We did not observe any tDCS effects on sleep stage ratio after intervention. HD-tDCS on the DMPFC is effective in sleep promotion and daily sleepiness recovery in patients with chronic insomnia. These findings demonstrate that HD-tDCS is a possibly promising therapy to supplement medication and cognitive behavioral therapy for chronic insomnia that requires replication and additional safety data.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.