ArticleScientific reports2025
Memory dependent modulation of hippocampal theta power through frontoparietal phase synchronous brain stimulation.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Precision non-invasive transcranial electromagnetic stimulation: a thematic review of optimizing spatial, temporal, and dose dimensions.European archives of psychiatry and clinical neuroscience · 2026Review
- Dual-site theta stimulation modulates connectivity, but not sequence memory in older adults.Brain communications · 2026Article
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Authors and funding
8 authors.
Funding
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Abstract
Targeting subcortical regions like the hippocampus with non-invasive brain stimulation is challenging due to predominantly cortical distribution of electric fields. Frontoparietal phase-synchronous transcranial alternating stimulation (tACS) offers a promising approach to modulate hippocampal functions, though its ability to induce modulation of oscillatory activity in deep subcortical targets remains to be shown. In this pilot study, we applied dual-site theta-tACS (in-phase between left frontoparietal regions) during a temporal order memory task. To quantify hippocampal activity and connectivity, we performed subcortical source analyses of electroencephalography (EEG) data using a hierarchical subspace pursuit algorithm. While memory did not differ between tACS and sham conditions, we observed tACS-induced increases in hippocampal theta power and its connectivity in individuals with superior memory performance. This study provides first-time evidence that phase-synchronized tACS over lateral frontoparietal areas influences hippocampal theta oscillatory activity, substantiating its potential to modulate hippocampal functions in health and disease.
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