ArticleNature communications2025
Coupling chromosome organization to genome segregation in Archaea.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Review
- Sulfolobales: Acidothermophilic archaea as models for biology and biotechnological applications.Engineering microbiology · 2026Review
- Successive waves of transcriptional repression and de-repression license cell cycle progression in an archaeon.Nucleic acids research · 2026Article
- Coordination of chromosome segregation and cell division in the archaeon Sulfolobus acidocaldarius.Nature communications · 2025Article
- Regulation of eukaryotic-like cell cycle progression in archaea is coming into focus.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Temporal and spatial coordination of DNA segregation and cell division in an archaeon.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Hypothesis that ancestral eukaryotes sexually proliferated without kinetochores or mitosis.Journal of cell science · 2025Article
- Archaeal SegAB forms a bipolar structure that promotes chromosome segregation in spherical cells.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
Chromosome segregation is a fundamental process in all life forms and requires coordination with genome organization, replication and cell division. The mechanism that mediates chromosome segregation in archaea remains enigmatic. Previously, we identified two proteins, SegA and SegB, which form a minimalist chromosome partition machine in Sulfolobales. Here we uncover patterns and mechanisms that SegAB employ to link chromosome organization to genome segregation. Deletion of the genes causes growth and chromosome partition defects. ChIP-seq investigations reveal that SegB binds to multiple sites scattered across the chromosome, but mainly localised close to the segAB locus in most of the examined archaeal genera. The sites are predominantly present in intragenic regions and enriched in one of the two compartments into which the chromosome folds. We show that SegB coalesces into multiple foci through the nucleoid, exhibiting a biased localisation towards the cell periphery, which hints at potential tethers to the cell membrane. Atomic force microscopy experiments disclose short-range DNA compaction and long-range looping of distant sites by SegB, pointing to a significant role for SegB in chromosome condensation that in turn enables genome segregation. Collectively, our data put forward SegAB as important players in bridging chromosome organization to genome segregation in archaea.
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Registered trials
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