Evidence map›Paper›PMID 40695804›Full record

ArticleNature communications2025

The bile acid-sensitive ion channel is gated by Ca

Makayla M Freitas, Eric Gouaux

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Makayla M FreitasVollum Institute, Oregon Health and Science University, 3232 SW Research Drive, Portland, OR, USA.
Eric GouauxVollum Institute, Oregon Health and Science University, 3232 SW Research Drive, Portland, OR, USA. gouauxe@ohsu.edu.ORCID http://orcid.org/0000-0002-8549-2360

Funding

3D STRUCTURE/FUNCTION OF LIGAND GATED ION CHANNELSR01NS038631 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI GOUAUX, JAMES E · 1999 to 2024
$6.7M
3D Structure and Function of Ligand-Gated Ion ChannelsR37NS038631 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI James E Gouaux · 2009 to 2026
$4.1M
The molecular architecture and mechanism of the Proton Activated Chloride (PAC) Channel.F31NS120713 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI FREITAS, MAKAYLA · 2020 to 2021
$44k
National Science Foundation (NSF) NSFGRFP-1000271223NINDS NIH HHS F31 NS120713NINDS NIH HHS R01 NS038631NINDS NIH HHS R37 NS038631U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 5R02NS038631U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) F31NS120713
6 · The paper itself

Abstract

The bile acid-sensitive ion channel (BASIC) is the least understood member of the mammalian epithelial Na

Indexed as

Bile Acids and SaltsCalciumEpithelial Sodium ChannelsIon Channel GatingAnimalsBinding SitesCryoelectron MicroscopyHEK293 CellsHumansModels, MolecularProtein ConformationProtein DomainsBile Acids and SaltsCalciumEpithelial Sodium Channels

Identifiers

PMID40695804
PMCPMC12283945

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.