Evidence map›Paper›PMID 40695537›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2025

Transcriptomic analyses of peripheral blood mononuclear cells reveal age-specific basal and acute exercise responsiveness differences in humans.

Bradley A Ruple, Nicholas A Carlini, Jason S Kofoed, Helya Rostamkhani, Brady E Hanson, Isaac Wilcox, Jesse C Craig, Shelby C Osburn, Micah J Drummond, Ryan M Broxterman and 1 more

Abstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Multicellular senescence programs in the aged heart.Journal of molecular and cellular cardiology plus · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bradley A RupleGeriatric Research, Education, and Clinical Center, George E. Wahlen Department VA Medical Center, Salt Lake City, Utah, United States.ORCID 0009-0001-7277-0771
Nicholas A CarliniGeriatric Research, Education, and Clinical Center, George E. Wahlen Department VA Medical Center, Salt Lake City, Utah, United States.ORCID 0000-0002-1632-1947
Jason S KofoedDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States.ORCID 0009-0002-6356-5837
Helya RostamkhaniDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States.
Brady E HansonGeriatric Research, Education, and Clinical Center, George E. Wahlen Department VA Medical Center, Salt Lake City, Utah, United States.ORCID 0000-0002-4495-3028
Isaac WilcoxDivision of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States.
Jesse C CraigGeriatric Research, Education, and Clinical Center, George E. Wahlen Department VA Medical Center, Salt Lake City, Utah, United States.ORCID 0000-0001-5959-4139
Shelby C OsburnDepartment of Health and Exercise Science, Colorado State University, Fort Collins, Colorado, United States.ORCID 0000-0003-3299-2289
Micah J DrummondDepartment of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, Utah, United States.ORCID 0000-0001-5961-8890
Ryan M BroxtermanGeriatric Research, Education, and Clinical Center, George E. Wahlen Department VA Medical Center, Salt Lake City, Utah, United States.ORCID 0000-0002-7388-2214
Joel D TrinityGeriatric Research, Education, and Clinical Center, George E. Wahlen Department VA Medical Center, Salt Lake City, Utah, United States.ORCID 0000-0001-8271-6536

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction during DisuseR01HL142603 · NHLBI · UNIVERSITY OF UTAH · PI TRINITY, JOEL DOUGLAS · 2019 to 2023
$2.9M
CSRD VA IK2 CX002114HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL142603NCI NIH HHS P30 CA042014NHLBI NIH HHS R01 HL142603RRD VA I01 RX003810RRD VA IK2 RX003913U.S. Department of Veterans Affairs (VA) I02RX003810U.S. Department of Veterans Affairs (VA) IK2RX003913
6 · The paper itself

Abstract

Aging is associated with alterations in immune cell function, contributing to age-related diseases and frailty. As peripheral blood mononuclear cells (PBMCs) are key drivers of the immune response, we investigated their transcriptome using RNA-sequencing before and immediately after a single bout of high-intensity knee-extension exercise in young (young;

Indexed as

AgingExerciseLeukocytes, MononuclearTranscriptomeAdultAgedAge FactorsFemaleGene Expression ProfilingHumansKiller Cells, NaturalMaleMiddle AgedYoung Adultagingexerciseimmune functionperipheral blood mononuclear cellstranscriptomics

Identifiers

PMID40695537
PMCPMC12352121

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.