Evidence map›Paper›PMID 40695524›Full record

ReviewZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2025

[Research progress on the cGAS-STING signaling pathway in immune-mediated inflammatory diseases in children].

Xin-Yue Wei, Xiao-Juan Gong, Hong Ji

Abstract readReviewEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Review in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Extracellular cGAMP in health and disease.Molecular biomedicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xin-Yue WeiDepartment of Pediatrics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, China.
Xiao-Juan GongDepartment of Pediatrics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, China.
Hong JiDepartment of Pediatrics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon gene (STING) signaling pathway is a crucial component of the immune system. It detects abnormal cytosolic double-stranded DNA and promotes the expression of type I interferons and other inflammatory factors, thereby protecting the body from pathogenic infections. In children, an immature immune system or genetic mutations can lead to immune dysregulation, increasing the risk of autoimmune diseases (AID) and autoinflammatory diseases. Recent studies have shown that aberrant activation of the cGAS-STING signaling pathway is associated with the development of AID and autoinflammatory diseases in children. This review summarizes the research progress on the cGAS-STING signaling pathway in childhood AID and autoinflammatory diseases, aiming to provide new directions for clinical diagnosis and treatment.

Indexed as

Autoimmune DiseasesInflammationMembrane ProteinsNucleotidyltransferasesSignal TransductionChildCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHumansSTING ProteincGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseMembrane ProteinsNucleotidyltransferasesSTING1 protein, humanSTING ProteinAutoimmune diseaseautoinflammatory diseasesChildCyclic GMP-AMP synthaseSignaling pathwayStimulator of interferon gene

Identifiers

PMID40695524
PMCPMC12291564

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.