ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2025
Detection and Remediation of Pneumocystis murina Infections by Environmental Health Monitoring.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increased sensitivity of PCR testing for environmental health monitoring compared with soiled bedding sentinel (SBS) serology can identify rodent pathogens thought to be excluded from a research animal facility. Exhaust dust testing for rodent pathogen surveillance revealed the presence of Pneumocystis murina in 3 colonies that was undetected in previous years of SBS serologic testing. This case series describes the process of follow-up testing used to identify and eliminate or isolate animals infected with P. murina. PCR testing of exhaust dust at the rack, row, and cage level on individually ventilated cage (IVC) racks was leveraged to identify all infected cages. Based on our experience, IVCs and standard cage handling practices are sufficient to contain this organism in mice with altered immune systems, which can harbor chronic P. murina infections. Institutions with an active mouse import program are at ongoing risk of accepting P. murina-positive animals from institutions still relying on SBS serology to identify this pathogen. PCR testing of rodent cage-generated dust can be used to pinpoint P. murina-infected mice housed on IVC racks.
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