Evidence map›Paper›PMID 40695460›Full record

Trial reportExperimental physiology2026

Effect of moderate altitude and nocturnal oxygen therapy on cerebrovascular function in patients with COPD: A randomized, crossover trial at 2048 m.

Dominic Gilliand, Tsogyal D Latshang, Sayaka S Aeschbacher, Fabienne Huber, Deborah Flueck, Mona Lichtblau, Stefanie Ulrich, Elisabeth D Hasler, Philipp M Scheiwiller, Julian Müller and 3 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dominic GilliandDepartment of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland.
Tsogyal D LatshangDepartment of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland.
Sayaka S AeschbacherDepartment of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland.
Fabienne HuberDepartment of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland.
Deborah FlueckDepartment of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland.
Mona LichtblauDepartment of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland.
Stefanie UlrichDepartment of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland.
Elisabeth D HaslerDepartment of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland.
Philipp M ScheiwillerDepartment of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland.
Julian MüllerDepartment of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland.
Silvia UlrichDepartment of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland.
Konrad E BlochDepartment of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland.
Michael FurianDepartment of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland.ORCID 0000-0002-8518-5029

Funding

Lunge ZürichSwiss National Science Foundation 143875
6 · The paper itself

Abstract

We investigated whether nocturnal oxygen therapy improves next-day cerebrovascular function in lowlanders with chronic obstructive pulmonary disease (COPD) staying at moderate altitude. This randomized, placebo-controlled single-blind crossover trial was performed in moderate-to-severe COPD patients [forced expiratory volume in 1 s (FEV

Indexed as

AltitudeCerebrovascular CirculationOxygen Inhalation TherapyPulmonary Disease, Chronic ObstructiveAgedCross-Over StudiesFemaleHumansMaleMiddle AgedOximetryOxygenOxygen SaturationSingle-Blind MethodOxygencerebrovascular reactivitychronic obstructive pulmonary diseasehypoxiatranscranial Doppler ultrasound

Identifiers

PMID40695460
PMCPMC12857471

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.