Evidence map›Paper›PMID 40695223›Full record

ArticleHormones and behavior2025

Mineralocorticoid receptor deletion alters spontaneous behavior in an automated home-cage monitoring apparatus.

Dalisa R Kendricks, Sarah Jo Sleiman, Sydney A Fry, Jariatu Stallone, Briana J Bernstein, Korey D Stevanovic, Leslie R Aksu, Georgia M Alexander, Katharine E McCann, Serena M Dudek and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hormones and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dalisa R KendricksNational Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA. Electronic address: dalisa.kendricks@nih.gov.
Sarah Jo SleimanNational Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA; University of North Carolina, Chapel Hill, NC, USA.
Sydney A FryNational Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA; University of Colorado School of Medicine, University of Colorado, CO, USA.
Jariatu StalloneNational Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Briana J BernsteinNational Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA; Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC, USA.
Korey D StevanovicNational Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Leslie R AksuNational Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Georgia M AlexanderNational Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Katharine E McCannNational Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA; Georgia Institute of Technology, Atlanta, GA, USA.
Serena M DudekNational Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Jesse D CushmanNational Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.

Funding

Mechanisms Of Synaptic Plasticity In The Adult And Developing Nervous SystemZIAES100221 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DUDEK, SERENA M · 2009 to 2025
$47.4M
Neurobehavioral Core LaboratoryZICES103330 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CUSHMAN, JESSE · 2018 to 2025
$13.3M
Intramural NIH HHS ZIA ES100221Intramural NIH HHS ZIC ES103330
6 · The paper itself

Abstract

Mineralocorticoid receptors (MRs) are transcription factors expressed throughout the body and brain, with especially high expression in the hippocampal area CA2. MRs are essential for maintaining the physiological stress response and regulating the hypothalamic-pituitary adrenal (HPA) axis. Further, MRs function through the diurnal modulation of corticosterone activity. The aim of the current study was to determine the role MRs play in the modulation of spontaneous behavior throughout the day/night cycle. Three conditional MR knockout mouse lines were utilized: one with broad embryonic neuronal deletion (Nestin-Cre), one with embryonic forebrain deletion (EMX-Cre), and one with postnatal CA2-targeted deletion (Amigo2-Cre). Behavior in these strains was assessed using an automated home cage monitoring system to track spontaneous behavior over a 60-h period. Broad deletion of MRs disrupted behavior in a sex-dependent manner, with alteration in motor activity and shelter behavior at night. Forebrain deletion of MRs produced similar, but less pronounced, differences in motor activity and shelter behavior, while CA2-targeted deletion produced little alteration in behavior either during the day or at night. These findings provide evidence for the essential role of MRs in the regulation of behavior across the day/night cycle and shed a light on the role of MR development and expression on behavior.

Indexed as

Behavior, AnimalReceptors, MineralocorticoidAnimalsCircadian RhythmFemaleMaleMiceMice, KnockoutMotor ActivityProsencephalonReceptors, MineralocorticoidMineralocorticoidPhenoTyperRodent behaviorSpontaneous behavior

Identifiers

PMID40695223
PMCPMC13188202

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.