Evidence map›Paper›PMID 40694848›Full record

ReviewNucleic acids research2025

The extended mobility of plasmids.

Maria Pilar Garcillán-Barcia, Fernando de la Cruz, Eduardo P C Rocha

Abstract readReview
In one paragraph

Review in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
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  6. The Origins of GPCRs.International journal of molecular sciences · 2026
    Review
  7. Article
  8. Article
  9. Article
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  16. An ISFrontiers in microbiology · 2026
    Article
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  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maria Pilar Garcillán-BarciaInstituto de Biomedicina y Biotecnología de Cantabria (Consejo Superior de Investigaciones Científicas - Universidad de Cantabria), 39011 Santander, Cantabria, Spain.ORCID 0000-0001-7058-5428
Fernando de la CruzInstituto de Biomedicina y Biotecnología de Cantabria (Consejo Superior de Investigaciones Científicas - Universidad de Cantabria), 39011 Santander, Cantabria, Spain.ORCID 0000-0003-4758-6857
Eduardo P C RochaInstitut Pasteur, Université Paris Cité, CNRS UMR3525, Microbial Evolutionary Genomics, 75015 Paris, France.ORCID 0000-0001-7704-822X

Funding

Institut Pasteur PIA/ANR-16-CONV-0005Laboratoire d'Excellence IBEID Integrative Biology of Emerging Infectious Diseases ANR-10-LABX-62-IBEIDSpanish Ministry of Science and Innovation MCIN/AEI/10.13039/501100011033 PID2020-117923GB-I00
6 · The paper itself

Abstract

Plasmids play key roles in the spreading of many traits, ranging from antibiotic resistance to varied secondary metabolism, from virulence to mutualistic interactions, and from defense to antidefense. Our understanding of plasmid mobility has progressed extensively in the last few decades. Conjugative plasmids are still often the textbook image of plasmids, yet they are now known to represent a minority. Many plasmids are mobilized by other mobile genetic elements, some are mobilized as phages, and others use atypical mechanisms of transfer. This review focuses on recent advances in our understanding of plasmid mobility, from the molecular mechanisms allowing transfer and evolutionary changes of plasmids to the ecological determinants of their spread. In this emerging, extended view of plasmid mobility, interactions between mobile genetic elements, whether involving exploitation, competition, or elimination, affect plasmid transfer and stability. Likewise, interactions between multiple cells and their plasmids shape the latter patterns of transfer through transfer-mediated bacterial predation, interference, or eavesdropping in cell communication, and by deploying defense and antidefense activity. All these processes are relevant for microbiome intervention strategies, from plasmid containment in clinical settings to harnessing plasmids in ecological or industrial interventions.

Indexed as

BacteriaGene Transfer, HorizontalPlasmidsBacteriophagesConjugation, GeneticHumansInterspersed Repetitive Sequences

Identifiers

PMID40694848
PMCPMC12282955

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.