Evidence map›Paper›PMID 40694809›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA2025

Human performance evaluation of a pediatric artificial intelligence sepsis model.

Swaminathan Kandaswamy, Naveen Muthu, Nikolay Braykov, Rebekah Carter, Reena Blanco, Thuy Bui, Evan Orenstein, Mark Mai

Abstract read
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Swaminathan KandaswamyPediatrics, Emory University School of Medicine, Atlanta, GA, 30307, United States.ORCID 0000-0003-2109-5769
Naveen MuthuPediatrics, Emory University School of Medicine, Atlanta, GA, 30307, United States.
Nikolay BraykovInformation Systems & Technology, Children's Healthcare of Atlanta, Atlanta, GA, 30329, United States.
Rebekah CarterEmergency Medicine, Children's Healthcare of Atlanta, Atlanta, GA, 30329, United States.
Reena BlancoPediatrics, Emory University School of Medicine, Atlanta, GA, 30307, United States.
Thuy BuiEmergency Medicine, Children's Healthcare of Atlanta, Atlanta, GA, 30329, United States.
Evan OrensteinPediatrics, Emory University School of Medicine, Atlanta, GA, 30307, United States.ORCID 0000-0003-3756-8575
Mark MaiPediatrics, Emory University School of Medicine, Atlanta, GA, 30307, United States.ORCID 0000-0003-0346-5818

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Institutional Career Development CoreKL2TR002381 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Anandi Nayan Sheth · 2017 to 2026
$14.1M
AHRQ HHS R03 HS029417National Center for Advancing Translational ScienceNCATS NIH HHSNIH HHS 5R03HS029417-02NIH HHS KL2TR002381NIH HHS UL1TR002378NLM NIH HHS
6 · The paper itself

Abstract

objectiveTo assess the influence of an implemented artificial intelligence model predicting pediatric sepsis (defined by IPSO-Improving Pediatric Sepsis Outcomes collaborative) in the emergency department (ED) on human performance measures. MATERIALS AND

methodsTwo ED sites within a large pediatric health system in the Southeastern United States between January 1, 2021 and April 1, 2024. We interviewed ED providers and nurses within 72 hours of caring for a patient identified as potentially having sepsis by the predictive model. Thematic analysis of qualitative data was combined with electronic health record queries to assess measures of human performance, including situation awareness, explainability, human-computer agreement, workload, trust, automation bias, and relationship between staff and patients.

resultsWe interviewed 40 clinicians. Participants found that the sepsis alert improved situation awareness, leading to changes in patient care management, resource allocation, and/or monitoring. Participants reported an average trust in the model-based alert of 3.8/5. Only 28% (555/1977) of sepsis huddles were done without alert firing, suggesting some automation bias. Treatment with antibiotics for IPSO sepsis cases was similar pre- and post-intervention without a huddle (9.3% vs 10.5%), though treatment doubled with huddle intervention (22.7%). NASA Task Load Index increased from 43 to 57 post-intervention. There was no report of adverse relationships with patients post-intervention. DISCUSSION: Human performance appeared to be generally positive with improved situation awareness and satisfaction with the alert-driven huddle. However, there was some evidence of automation bias and a slight increase in workload with the intervention.

conclusionThis study demonstrates the feasibility of evaluating multiple dimensions of human performance using a mixed methods approach for an AI model implemented in clinical practice. Future studies should aim to reduce the measurement burden of human performance metrics associated with AI implementation in acute care settings and assess the correlation between human performance measures and clinical outcomes.

Indexed as

Artificial IntelligenceDecision Support Systems, ClinicalEmergency Service, HospitalSepsisChildElectronic Health RecordsHumansartificial intelligenceemergency departmentevaluationhuman factorshuman performancepediatricssepsis

Identifiers

PMID40694809
PMCPMC12451936

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.