ArticleNeurology(R) neuroimmunology & neuroinflammation2025
KFLC to Total CSF Protein Ratio Is an Alternative to KFLC Index to Diagnose Multiple Sclerosis: A Retrospective Study of 814 Cases.
Article in Neurology(R) neuroimmunology & neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Kappa index: real-world study for assessing cut-off values that provide the best accuracy for multiple sclerosis diagnosis in patients with CIS.Frontiers in immunology · 2026Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesBiological analyses are crucial for diagnosing multiple sclerosis (MS), notably detection of oligoclonal bands (OCBs) of immunoglobulin G in CSF. Kappa free light chain (KFLC) quantification in serum and CSF has recently been proposed as an additional test. In a rational medicoeconomic approach, identifying algorithms or biomarkers is important. The objective of this study was, therefore, to evaluate the correlation between CSF kappa free light chain (KFLC
methodsKFLC measurements were performed prospectively with each OCB analysis, and the data were interpreted retrospectively. A total of 814 clinical cases were included: 153 with MS or clinically isolated syndrome (CIS), 181 with other inflammatory neurologic diseases, and 480 with noninflammatory neurologic diseases. Performances of KFLC
resultsKFLC DISCUSSION: To conclude, KFLC CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that the KFLC
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