ArticleNucleic acids research2025
Evidence that transient replication errors initiate nuclear genome mutations.
Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Two distinct Okazaki fragment failure modes dominate mutagenesis in the absence of flap endonuclease 1.Nature communications · 2026Article
- Extended sequence context shapes mutational bias inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Evidence that MutSβ repairs indels generated by mispair initiated template slippage.DNA repair · 2026Article
- Dynamic Assemblies in Genome Maintenance.Advances in experimental medicine and biology · 2026Review
- The A, B, C, D's of replicative DNA polymerase fidelity: utilizing high-throughput single-molecule sequencing to understand the molecular basis for DNA polymerase accuracy.Nucleic acids research · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
DNA synthesis during genomic replication generates mismatches that lead to mutations. Point mutations may be caused by base-base mismatches that yields base substitutions or by primer- or template-strand slippage, which yield insertions and deletions (indels), respectively. Evidence obtained 40 years ago with DNA polymerases in vitro indicated that transient DNA intermediates also initiate substitutions and indels. Here, we provide evidence in vivo that the rates of specific single-base mutations at or adjacent to the 3'-terminus of the primer strand of mononucleotide runs increase change with run length. We propose that four such TIM (transient initiator mutagenesis) pathways are active during replication of the yeast nuclear genome in vivo and may be a universal feature of DNA replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.