Evidence map›Paper›PMID 40694666›Full record

ArticleBiochemistry2025

(Reverse) Evolution of a Promiscuous Isochorismate Pyruvate Lyase into an Efficient Chorismate Mutase.

Dominik E Künzler, Luca Bressan, Linda Jäger, Marianne Gamper, Peter Kast

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dominik E KünzlerLaboratory of Organic Chemistry, ETH Zurich, CH-8093 Zurich, Switzerland.
Luca BressanLaboratory of Organic Chemistry, ETH Zurich, CH-8093 Zurich, Switzerland.
Linda JägerLaboratory of Organic Chemistry, ETH Zurich, CH-8093 Zurich, Switzerland.
Marianne GamperLaboratory of Organic Chemistry, ETH Zurich, CH-8093 Zurich, Switzerland.
Peter KastLaboratory of Organic Chemistry, ETH Zurich, CH-8093 Zurich, Switzerland.ORCID 0000-0002-0209-8975

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PchB is an isochorismate pyruvate lyase (IPL) involved in siderophore biosynthesis in

Indexed as

Bacterial ProteinsChorismate MutaseDirected Molecular EvolutionOxo-Acid-LyasesCatalytic DomainChorismic AcidEscherichia coliKineticsModels, MolecularPseudomonas aeruginosaBacterial ProteinsChorismate Mutasechorismate pyruvate lyaseChorismic Acidisochorismic acidOxo-Acid-Lyases

Identifiers

PMID40694666
PMCPMC12329711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.