Evidence map›Paper›PMID 40694503›Full record

ArticleThe Journal of physiology2025

Mechanisms underlying local Ca

Joon-Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun-Hee Woo

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joon-Chul KimCollege of Pharmacy, Chungnam National University, Yuseong-gu, Daejeon, South Korea.ORCID https://orcid.org/0000-0002-4909-9246
Hieu Trong HuynhCollege of Pharmacy, Chungnam National University, Yuseong-gu, Daejeon, South Korea.
Phuong Kim LuongCollege of Pharmacy, Chungnam National University, Yuseong-gu, Daejeon, South Korea.ORCID https://orcid.org/0009-0003-8048-936X
Tran Nguyet TrinhCollege of Pharmacy, Chungnam National University, Yuseong-gu, Daejeon, South Korea.ORCID https://orcid.org/0000-0003-4209-8248
Yixuan WuDepartment of Pharmacology, University of California Davis, Davis, California, USA.
Eleonora GrandiDepartment of Pharmacology, University of California Davis, Davis, California, USA.ORCID https://orcid.org/0000-0002-4401-8857
Sun-Hee WooCollege of Pharmacy, Chungnam National University, Yuseong-gu, Daejeon, South Korea.ORCID https://orcid.org/0000-0003-1444-3438

Funding

Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI Joseph C. Wu · 2019 to 2026
$21.1M
Sex-specific arrhythmogenic mechanisms of atrial fibrillationR01HL131517 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2016 to 2026
$5.0M
Multiomics and Functional Characterization Establish Druggable Targets for PVC-Driven Idiopathic VFR01HL170521 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Eleonora Grandi · 2023 to 2026
$3.1M
Calcium Driven Fibroblast Dysregulation in Human Atrial Profibrotic RemodelingR01HL176651 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2025 to 2026
$1.1M
American Heart Association Postdoctoral fellowship 24POST1195229National Heart, Lung, and Blood Institute grants P01HL141084National Heart, Lung, and Blood Institute grants R01HL131517National Heart, Lung, and Blood Institute grants R01HL170521National Heart, Lung, and Blood Institute grants R01HL176651National Research Foundation of Korea (NRF) RS-2022-NR070455National Research Foundation of Korea (NRF) RS-2022-NR070856NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R01 HL131517NHLBI NIH HHS R01 HL170521NHLBI NIH HHS R01 HL176651
6 · The paper itself

Abstract

Changes in heart rate affect Ca

Indexed as

frequencylocal Ca2+ signallingright and left atrial myocytesSERCA2SR Ca2+ content

Identifiers

PMID40694503
PMCPMC12329750

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.