Evidence map›Paper›PMID 40694486›Full record

ArticleJournal of the American Chemical Society2025

Enzymatic Stereodivergent Synthesis of Azaspiro[2.y]alkanes.

Jennifer L Kennemur, Yueming Long, Catherine J Ko, Anuvab Das, Frances H Arnold

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Enantioselective Access to Trifluoromethylated Spirocyclopropyl Heterocycles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jennifer L KennemurDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID 0000-0002-4835-1139
Yueming LongDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID 0009-0006-5112-7791
Catherine J KoDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
Anuvab DasDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID 0000-0002-9344-4414
Frances H ArnoldDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.ORCID 0000-0002-4027-364X

Funding

Development of Biocatalysts for Chemodivergent Functionalizations of HeterocyclesF32GM143797 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI KENNEMUR, JENNIFER L. · 2022 to 2024
$210k
NIGMS NIH HHS F32 GM143797
6 · The paper itself

Abstract

Azaspiro[2.y]alkanes are increasingly valuable scaffolds in pharmaceutical drug discovery; however, an asymmetric catalytic method for their synthesis remains unknown. Here, we present a stereodivergent carbene transferase platform for the cyclopropanation of unsaturated exocyclic

Indexed as

AlkanesAza CompoundsSpiro CompoundsTransferasesBiocatalysisEscherichia coliStereoisomerismAlkanesAza CompoundsSpiro CompoundsTransferases

Identifiers

PMID40694486
PMCPMC12951711

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.