Effective cerebellar neuroprosthetic control after stroke.

Rohit Rangwani, Aamir Abbasi, Tanuj Gulati

Abstract read

In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Rohit RangwaniCenter for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Aamir AbbasiCenter for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Tanuj GulatiCenter for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: tanuj.gulati@csmc.edu.

Funding

A Neurophysiological Approach to Post-Stroke Motor RecoveryR01NS128469 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI Tanuj Gulati · 2023 to 2026

$1.7M

Closed-loop Brain Stimulation for Motor Recovery Post StrokeR00NS097620 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI GULATI, TANUJ · 2019 to 2021

$747k

NINDS NIH HHS R00 NS097620NINDS NIH HHS R01 NS128469

6 · The paper itself

Abstract

Brain-machine interfaces (BMIs) offer a viable option for restoring function in patients with motor disabilities post-stroke. Most BMI systems rely on signals from the motor cortex (M1), which is often compromised after stroke. The cerebellum, a subcortical structure involved in motor control, remains an underexplored source for neuroprosthetic control. Using chronic electrophysiological recordings in a rat stroke model, we show that cerebellar neural activity can effectively drive BMI control, performing comparably to M1-driven control. We observed this even in animals with motor impairments post-stroke. Simultaneous M1-cerebellum recordings during cerebellar BMI control revealed that cerebellar "direct" neurons driving the interface were influenced by both local cerebellar and distant M1 neurons. While cerebellar influence remained stable, M1's interaction with cerebellar direct neurons shifted from longer to shorter timescales after stroke. These findings highlight that cerebellar direct neural control is possible in the stroke brain and reveal changes in M1-cerebellar network dynamics post-stroke.

Indexed as

Brain-Computer InterfacesCerebellumStrokeAnimalsDisease Models, AnimalMaleMotor CortexNeuronsRatsbrain-machine interfacecerebellumcortico-cerebellar networkCP: Neuroscienceinter-area communicationmotor cortexneural plasticityneuroprostheticsneurorehabilitationpost-stroke compensationstroke

Identifiers

PMID40694476

DOI10.1016/j.celrep.2025.116030

PMCPMC12453015

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.