Observational studyJornal brasileiro de nefrologia
The association between the Kidney Donor Profile Index and one-year outcomes in Brazilian kidney transplant recipients of standard criteria donors.
Observational study in Jornal brasileiro de nefrologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Assessing kidney donor quality: the saga continues.Jornal brasileiro de nefrologiaArticle
- Comment on "The association between the Kidney Donor Profile Index and one-year outcomes in Brazilian kidney transplant recipients of standard criteria donors".Jornal brasileiro de nefrologiaArticle
- Reply to the comment on the "Association between the Kidney Donor Profile Index and one-year outcomes in Brazilian kidney transplant recipients of standard criteria donors".Jornal brasileiro de nefrologiaArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe Kidney Donor Profile Index (KDPI) has not been previously validated in Brazil, thus this study aimed to investigate the association between the index and one-year outcomes in kidney transplant recipients (KTRs) of standard criteria donors (SCD).
methodsRetrospective cohort analysis including 1,943 KTRs who received kidneys from SCD between 2013 and 2017. The primary outcome was composed of death, graft loss, and 1-yr-graft function <30 mL/min/1.73m2 (eGFR, CKD-EPI). Logistic regression identified variables associated with the primary outcome, while 1-yr eGFR across KDPI strata was compared using the Kruskal-Wallis test, adjusted with the Bonferroni test.
resultsDonors were 41.0 years old, 24.9% had hypertension, 47.3% died due to cerebrovascular injury, and 48.3% had the final creatinine >1.5 mg/dL; the median of KDPI was 52%. The primary outcome occurred in 14.4% of the cases, which was associated with longer dialysis duration before transplantation (p = 0.04), CMV-related events (p = 0.03), acute rejection (p < 0.001), and KDPI strata. Compared to the 1-35% KDPI stratum, the RRs for the primary outcome were significantly higher in higher KDPI strata: 1.62 (p = 0.03) for >35-50%, 2.28 (p < 0.001) for >50-85%, and 2.23 (p = 0.01) for >85%. The 1-yr eGFR was also significantly lower in KTRs with donors in higher KDPI strata (p < 0.001).
conclusionThe KDPI was independently associated with the primary outcome composed of death, graft loss, and 1-yr eGFR <30 mL/min/1.73 m2 in recipients of SCD donors. Despite not being previously validated for Brazilian donors, the KDPI was also significantly associated with 1-yr eGFR, delayed graft function, and acute rejection in those recipients.
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