Evidence map›Paper›PMID 40694338›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan.

Tejas Menon, Hayley A McQuilten, Jerome Samir, Thi H O Nguyen, Ratana Lim, Jasveen Kaur, Simone Rizzetto, Auda Eltahla, Paul G Thomas, Martha Lappas and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. The ageing immune system and its battle with viruses.The Journal of general virology · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Tejas MenonDepartment of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia.
Hayley A McQuiltenDepartment of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia.
Jerome SamirSchool of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Thi H O NguyenDepartment of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia.ORCID 0000-0002-9294-7693
Ratana LimDepartment of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC 3000, Australia.
Jasveen KaurSchool of Health Sciences and School of Medicine, University of Tasmania, Launceston, TAS 7248, Australia.
Simone RizzettoSchool of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Auda EltahlaSchool of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Paul G ThomasDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105.ORCID 0000-0001-7955-0256
Martha LappasDepartment of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC 3000, Australia.
Jamie RossjohnImmunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0002-2020-7522
Stephanie GrasImmunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Jane CroweDeepdene Surgery, Deepdene, VIC 3103, Australia.
Katie L FlanaganSchool of Health Sciences and School of Medicine, University of Tasmania, Launceston, TAS 7248, Australia.ORCID 0000-0002-1575-1953
Fabio LucianiSchool of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Peter C Doherty *Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia.
Carolien E van de Sandt *Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia.ORCID 0000-0002-4155-7433
Katherine Kedzierska *Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia.ORCID 0000-0001-6141-335X

Funding

DECODING THE INTERACTIONS BETWEEN T CELL RECEPTORS AND PEPTIDE-MHCR01AI136514 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Paul G. Thomas · 2018 to 2026
$6.9M
DYNAMICS AND EVOLUTION OF IMMUNE RESPONSES TO INFLUENZA VIRUSESU01AI150747 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, ANTIA, RUSTOM NOSHIR · 2020 to 2024
$5.9M
Federal Government | DHAC | National Health and Medical Research Council (NHMRC) 1173871NIAID NIH HHS R01 AI136514NIAID NIH HHS U01 AI150747
6 · The paper itself

Abstract

Central memory CD8

Indexed as

CD8-Positive T-LymphocytesImmunologic MemoryInfluenza, HumanMemory T CellsReceptors, Antigen, T-CellAdolescentAdultAgedChildChild, PreschoolFemaleHLA-A2 AntigenHumansInfantInfant, NewbornMaleHLA-A2 AntigenReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betacentral memoryhuman lifespaninfluenza-specific T cellsmemory T cellsT cell receptors

Identifiers

PMID40694338
PMCPMC12318230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.