ReviewProbiotics and antimicrobial proteins2026
The Role of Functional Feed in Modulating Fish Gut Microbiome to Enhance Resistance Against Aquaculture Pathogens.
Review in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Postbiotics and Paraprobiotics as Next-Generation Gut Microbiome Modulators in Sustainable Aquaculture Health.Antibiotics (Basel, Switzerland) · 2026Review
- The Effect of Low-Fishmeal Feed Including an Olive Leaf Extract (Animals : an open access journal from MDPI · 2026Article
- Article
- Physiological Responses of Fishes to Nutrition Management and Environmental Stresses.Animals : an open access journal from MDPI · 2026Article
- Functional Feeds as Immunostimulants for Aquaculture: A Molecular Perspective.Aquaculture nutrition · 2026Review
- Mechanistic investigation into the differences in growth performance and resistance to spring viremia of carp virus in common carp.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiome, comprising of diverse microbial species, plays a critical role in the immunological responses and physiological functions of fish. Functional feed components such as probiotics, prebiotics, immunostimulants (e.g. β-glucans), and bioactive compounds (e.g. phenolic compounds and terpenes) enhance disease resistance and overall health. This review highlights the diversity and composition of the fish gut microbiome and its significant role in immune modulation. It examines the ability of functional feed components, microbiome-associated metabolites, including antimicrobial peptides, bile acids, and short-chain fatty acids (SCFAs), to influence the fish immune system. Also, it focuses on the role of extracellular vesicles and quorum-sensing molecules in modulating gut health. Furthermore, high-throughput metabolomics techniques, such as gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR) spectroscopy, are utilised to analyse gut microbiome metabolites and optimise functional feeds. These characterisation techniques effectively detect the metabolites released in the microbiota for better feed utilisation. Functional feeds enhance growth performance by helping the fish to maintain stable gut microbiota, thus reducing the dependency on antibiotics. This review clearly establishes the transformative potential of different functional feeds for enhancing and promoting sustainable aquaculture practices. However, challenges such as horizontal gene transfer and long-term ecological impacts of microbiome alterations persist. Also, economic feasibility, regulations, and biosafety considerations may affect the widespread use of these functional feeds. Future studies should focus on refining feed formulations, understanding host-microbiome interactions, and leveraging advanced omics technologies to ensure ecological and economic sustainability in aquaculture systems.
Indexed as
Identifiers
40694305What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.