Evidence map›Paper›PMID 40694282›Full record

ArticleMolecular neurobiology2025

Genetically Elevated Neutrophil Count Is Associated with Poor Outcome Following Ischemic Stroke: A Mendelian Randomization Study.

Mengmeng Wang, Iyas Daghlas, Liping Cao, Zhizhong Zhang, Dipender Gill, Luolin Sha, Dandan Liu

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mengmeng WangDepartment of Neurology, The Third Affiliated Hospital of Soochow University, Changzhou, China. wangmeng_neuro@163.com.
Iyas DaghlasDepartment of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Liping CaoDepartment of Neurology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Zhizhong ZhangDepartment of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Dipender GillDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Luolin ShaDepartment of Neurology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Dandan LiuDepartment of Integrated Traditional Chinese and Western Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China.

Funding

Major Program of Science and Technology Project of Changzhou Health Commission ZD202403
6 · The paper itself

Abstract

The aim of this study was to investigate the association between genetically proxied white blood cell (WBC) subtype counts and functional outcome following ischemic stroke. Genetic proxies for counts of neutrophils, lymphocytes, monocytes, eosinophils, and basophils were identified from the Blood Cell Consortium genome-wide association study meta-analysis (N = 562,243 European participants). A poor post-stroke functional outcome was defined as a modified Rankin Scale (mRS) score > 2 at 3 months. Summary-level genetic associations with mRS > 2 (mRS 0-2 vs. 3-6) were obtained from the Genetics of Ischemic Stroke Functional Outcome network (N = 6021). Associations of genetically proxied WBC counts with functional outcome after ischemic stroke were estimated using the random-effects inverse variance weighted method. In univariable MR analysis, genetically proxied higher neutrophil count was nominally associated with poor functional outcome following ischemic stroke (OR = 1.33, 95% CI = 1.05-1.70; P = 0.020). This association was consistent in multivariable MR analysis adjusting for genetic associations with all other WBC subtypes (OR = 1.45, 95% CI = 1.06-1.99; P = 0.021). There were no associations between any other WBC subtypes counts and functional outcome following ischemic stroke. Our findings provide genetic evidence that genetically proxied neutrophil count was associated with poor functional outcome following ischemic stroke. Future studies are needed to replicate this finding and to investigate the molecular mechanisms underlying this association.

Indexed as

Ischemic StrokeMendelian Randomization AnalysisNeutrophilsAgedFemaleGenome-Wide Association StudyHumansLeukocyte CountMalePolymorphism, Single NucleotideTreatment OutcomeGWASMendelian randomization studyWhite blood cell

Identifiers

PMID40694282

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.