ArticleMolecular diversity2026
PPGBioPred: a webserver for predicting the bioactivity of compounds against PPARγ involved in the negative regulation of the Wnt/β-catenin signaling pathway.
Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Interpretable QSAR modelling for PPAR-γ agonist prediction by integrating a stacking strategy, docking, and MD simulations.Molecular diversity · 2026Article
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Authors and funding
2 authors.
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Abstract
The Wnt/β-catenin signaling pathway is a key regulator of cellular activities and has implications for various diseases. This study explored the ability to predict the bioactivities of compounds against the peroxisome proliferator-activated receptor γ (PPARγ), paving the way to develop PPGBioPred, a user-friendly webserver to modulate this pathway. The research employs computational methodologies, particularly quantitative structure-activity relationship (QSAR) models, to understand the bioactivity of compounds. The study evaluated the efficacy of twelve categories of fingerprint descriptors for model development and used the Gini index to reveal the molecular features crucial for the studied bioactivity of PPARγ. The resulting high-performing models - achieving external R
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Registered trials
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