Observational studyObesity surgery2025
Optimizing Bariatric Surgery Outcomes: The Dual Benefits of Preoperative Very-Low-Calorie Diets.
Observational study in Obesity surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Treating Severe Obesity: A Medical Perspective.Advances in therapy · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveWeight regain following metabolic and bariatric surgery (MBS) remains a major clinical challenge, particularly among individuals with metabolic abnormalities. This study aimed to evaluate the effect of preoperative very low-energy diet (VLED) on 1-year postoperative weight loss success and to explore its potential metabolic mediators.
methodsIn this prospective observational cohort study, 248 patients undergoing laparoscopic sleeve gastrectomy were allocated to either a VLED group (n = 124) or a non-VLED group (n = 124) with matched baseline characteristics. The primary outcome was defined as a ≥25% reduction in body mass index (BMI) at 12 months postoperatively. Subgroup, Cox regression, and mediation analyses were conducted to assess the impact of VLED and identify potential mediators including HbA1c, triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C).
resultsPatients in the VLED group demonstrated significantly higher rates of weight loss success (58.9% vs. 37.1%, P = 0.014) and greater improvements in metabolic parameters (HbA1c, HOMA-IR, TG, HDL-C). Cox regression revealed that VLED was associated with a lower risk of weight loss success failure (HR=0.62, P = 0.004), particularly among individuals with HOMA-IR >2.5. Mediation analysis showed that HbA1c reduction accounted for 31.1% of VLED's effect on weight loss success, followed by TG and HDL-C.
conclusionPreoperative VLED significantly enhances weight loss success after bariatric surgery, especially in patients with insulin resistance, with metabolic improvements in HbA1c, TG, and HDL-C partially mediating the beneficial effects. These findings support incorporating VLED into preoperative care for high-risk patients.
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Registered trials
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