Trial reportLasers in medical science2025
Does photobiomodulation before or after in-office dental bleaching influence sensitivity reduction? A randomized clinical trial.
Trial report in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06518629 (Photobiomodulation Before or After In-office Tooth Whitening for Sensitivity Reduction), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Photobiomodulation Before or After In-office Tooth Whitening for Sensitivity Reduction: a Blinded, Randomized, Controlled Study
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effect of photobiomodulation (PBM), applied before or after in-office dental bleaching, on the reduction of dental sensitivity and color change.
methodsSixty-six participants were randomized into three groups: Control (no additional treatments before or after dental bleaching), PBM-Before (PBM applied before dental bleaching), and PBM-After (PBM applied after dental bleaching). PBM was performed with infrared light at two points (apical and cervical) on the buccal surface of the teeth. The low-power laser operated in continuous mode (100 mW power), applying 2 J per point for 20 s. Bleaching treatment was performed using 35% hydrogen peroxide (3 sessions with a 1-week interval). The visual analog scale evaluated dental sensitivity during dental bleaching and up to 72 h after each session. Color was assessed at baseline and one week after the 3rd session.
resultsThe PBM-Before group did not differ statistically from the PBM-After group (p > 0.05). The PBM-Before group had lower dental sensitivity than the Control up to 1 h after the 2nd (p = 0.01) and 3rd bleaching sessions (p = 0.01). The PBM-After group showed lower dental sensitivity than the Control at the following times: during gel application in the 2nd (p = 0.03) and 3rd sessions (p = 0.006); up to 1 h after the 1st, 2nd, and 3rd sessions (p = 0.04, p = 0.007, p < 0.001, respectively); and between 1 and 24 h after bleaching in the 2nd (p = 0.005) and 3rd sessions (p < 0.001). PBM did not affect the bleaching outcome (p > 0.05).
conclusionPBM reduced dental sensitivity, with better results when applied after bleaching, without compromising color change.
trial registrationNCT06518629 (2024-07-15).
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