ArticleActa neurochirurgica2025
A comparison of electrophysiological microrecording versus automatic MR-based segmentation to determine subthalamic nucleus boundaries.
Article in Acta neurochirurgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeAccurate placement of electrodes within the subthalamic nucleus is critical for deep brain stimulation (STN-DBS) in Parkinson's disease (PD). Our objective was to compare microelectrode recording (MER) and an automatic MR-based segmentation tool (BrainLab Elements
methodsSeventy-eight PD patients were included. Electrode placement within the STN and STN entry and exit points were determined by both methods and compared for concordance.
resultsOf 344 trajectories, 269 were inside the STN, with good concordance of both techniques (Fleiss' kappa 0.721, [95%CI 0.623, 0.819]). Concordance of MER and MR-based for the selection of the optimal trajectory was good (Fleiss' kappa 0.693, [95%CI 0.578, 0.808]), with less than 2.75mm difference between MER and MR-based for the STN entry (upper limit of agreement 2.752 [95%CI 2.365 to 3.138] mm; lower limit of agreement -2.406 [95%CI -2.793 to -2.020] mm) and exit points (upper limit of agreement 2.750 [95%CI 2.351 to 3.149] mm; lower limit of agreement -2.577mm [95%CI -2.976 to -2.178]).
conclusionWe demonstrated that MER and MR-based segmentation have a good concordance to determine STN boundaries during DBS surgery.
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