ArticleInternational ophthalmology2025
The antibiotic resistance profiles of Staphylococcus in the Asia Cornea Society infectious keratitis study.
Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Antibiotic resistance patterns of methicillin-susceptible Staphylococcus aureus and methicillin-resistant Staphylococcus aureus isolates in keratitis: Insights from an 11-year analysis.Indian journal of ophthalmology · 2026Article
- Risk stratification and source classification inFrontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the antibiotic susceptibility profiles of Staphylococcus species, specifically S. aureus and S. epidermidis, collected from the Asia Cornea Society Infectious Keratitis Study (ACSIKS).
methodsIsolates were re-identified in this laboratory study, and antibiotic susceptibility was determined by broth microdilution. A panel of 11 antibiotics from 7 classes were tested. The minimum inhibitory concentration was determined based on Clinical Laboratory Standard Institute guidelines, where available. Isolates were classified as susceptible, intermediate, or resistant, with methicillin-resistance determined by oxacillin susceptibility. Multidrug resistance (MDR) was defined as resistance to at least one agent in three or more antimicrobial categories.
resultsA total of 490 staphylococci isolates were analyzed, with S. epidermidis (42%) and S. aureus (24.1%) the most prevalent. Vancomycin was universally effective against both species. However, resistance to the common fluoroquinolones was high in S. aureus (49.1%-51.6%) and S. epidermidis (36.9%-40.3%). Methicillin-resistance was present in 33.1% of S. aureus and 47.6% of S. epidermidis isolates. MDR was significantly associated with methicillin-resistance, with 85% of methicillin-resistant S. aureus and 66.3% of methicillin-resistant S. epidermidis exhibiting MDR.
conclusionAntibiotic resistance is common in Staphylococcus species causing infectious keratitis in Asia. High rates of resistance to the commonly used fluoroquinolones and the prevalence of MDR in methicillin-resistant isolates pose a major challenge. The findings emphasize the need for local data to guide treatment decisions and to consider alternative antibiotics in cases with multidrug resistance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.