ArticleActa neurochirurgica2025
The prognostic role of frailty on outcomes following meningioma resection in the elderly: a matched analysis employing baseline functional status.
Article in Acta neurochirurgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Sarcopenic obesity and cachexia as nutritional risk phenotypes and histology-specific outcomes after intracranial tumor resection: a histology-stratified NSQIP analysis of 27,057 cases.Neurosurgical review · 2026Article
- Awake craniotomy for brain tumor resection in the elderly: an institutional experience.Journal of neuro-oncology · 2026Article
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8 authors.
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Abstract
introductionMeningioma resection constitutes a substantial portion of neurosurgical practice, with a variety of patient-factors playing a role in outcomes. This study aims to assess the role of frailty in elderly patients undergoing resection of primary intracranial meningiomas.
methodsThis is a retrospective study of patients undergoing resection for primary intracranial meningiomas at our institution between 2004-2024. Patients were ≥ 65 years, and were required to have ≥ 1 year of follow-up. The modified frailty index (mFI) was used to identify degree of frailty, categorising patients into the non-frail (NF, mFI = 0), pre-frail (PF, mFI = 1/2), and frail (F, mFI ≥ 3) groups. The Shapiro-Wilk test, paired T-test, and ANOVA were used to identify statistical significance. Propensity-score matching (PSM) was performed based on a multinomial logistic regression model and 1:1 nearest-neighbour matching algorithm. Kaplan-Meier analysis using Log-rank tests were used to compare overall (OS) and progression-free (PFS) survival.
results362 patients were included, with 69, 207, and 86 patients in the NF, PF, and F groups respectively. Preoperatively, the F group was found to have a significantly higher age vs. the NF group (76.17 vs. 71.57, p = 0.0002), alongside reporting a significantly lower median KPS vs. the PF and NF groups (70 vs. 80, p < 0.0001) respectively. The PF group was found to have a significantly lower duration of surgery (309 min, p = 0.0048) vs. the F group, which reported significantly higher mean length-of-stay (17.68 days, p < 0.0001), higher frequencies of medical complications (11.6%, p = 0.0317), and lower postoperative KPS (70, p < 0.0001) vs. other groups. Despite PSM, the F group was found to have significantly reduced median OS (p = 0.0106) and PFS (p = 0.0101) compared to other groups.
conclusionFrailty was significantly associated with higher length-of-stay, frequent medical complications, and worse OS and PFS following surgery vs. other groups. Frailty is hence a crucial consideration in preoperative planning for elderly populations undergoing meningioma resection.
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