Evidence map›Paper›PMID 40694125›Full record

ArticleJournal of neurology2025

MOG-IgG detection in serum and cerebrospinal fluid: diagnostic implications and clinical correlates in adult-onset Chinese MOGAD patients.

Yuwei Dai, Qing Yin, Binhong Han, Tianxiang Yuan, Kai Su, Weiqi Dai, Dan Wang, Li Yang

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Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuwei Dai *Department of Neurology, Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, 410011, China.
Qing Yin *Department of Neurology, Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, 410011, China.
Binhong HanDepartment of Neurology, Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, 410011, China.
Tianxiang YuanDepartment of Neurology, Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, 410011, China.
Kai SuDepartment of Neurology, Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, 410011, China.
Weiqi DaiDepartment of Neurology, Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, 410011, China.
Dan WangDepartment of Anesthesiology, The Second Xiangya Hospital of Central South University, No.139 Middle Renmin Road, Changsha, 410011, Hunan, China. 505056@csu.edu.cn.
Li YangDepartment of Neurology, Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, 410011, China. yangli762@csu.edu.cn.ORCID http://orcid.org/0000-0001-5973-3653

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the diagnostic significance and clinical features of cerebrospinal fluid (CSF)-restricted MOG-IgG in Chinese adults with MOG-IgG-associated disease (MOGAD), and to compare phenotypes across MOG-IgG statuses and ethnicities.

methodsEighty-two adults with suspected inflammatory demyelinating diseases and positive MOG-IgG (serum and/or CSF) were retrospectively analyzed from 2014 to 2024. Patients were categorized into two groups based on MOG-IgG status: MOG-IgG Seropositive group (MOG-IgG Seropositive and CSF Negative) and CSF Positive group (MOG-IgG paired serum and CSF positive, CSF-restricted MOG-IgG). Clinical, radiological, and therapeutic features were evaluated. Logistic regression was used to identify predictors of poor prognosis. Literatures on CSF-restricted MOG-IgG in different ethnicities were reviewed.

resultsSix patients (7.3%) had CSF-restricted MOG-IgG, and 83.3% met MOGAD phenotypes. Optic neuritis was the most common presentation (54.8%), followed by cerebral cortical encephalitis and acute disseminated encephalomyelitis. Visual and motor impairments at onset were more frequent in the seropositive group. Independent risk factors for EDSS ≥ 3.0 included higher nadir EDSS score (OR: 2.39), visual impairment (OR: 10.94), and brainstem dysfunction (OR: 8.75).

conclusionsCSF-restricted MOG-IgG defines a distinct MOGAD subgroup, supporting its diagnostic relevance. Visual and brainstem involvement predict worse outcomes. Larger, multiethnic prospective studies are warranted to refine diagnostic thresholds and clarify the role of intrathecal antibody production.

Indexed as

AutoantibodiesDemyelinating Autoimmune Diseases, CNSImmunoglobulin GMyelin-Oligodendrocyte GlycoproteinMyelin Oligodendrocyte Glycoprotein Antibody-Associated DiseaseAdultAgedChinaEast Asian PeopleFemaleHumansMaleMiddle AgedOptic NeuritisRetrospective StudiesYoung AdultAutoantibodiesImmunoglobulin GMOG protein, humanMyelin-Oligodendrocyte GlycoproteinCerebrospinal fluidMOG-antibody-associated diseaseMyelin oligodendrocyte glycoprotein IgGPrognosis

Identifiers

PMID40694125

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.