Evidence map›Paper›PMID 40693920›Full record

ReviewACS chemical neuroscience2025

Aryl Guanyl Hydrazones: A Viable Strategy for Designing BBB-Permeable, Neuroactive Compounds?

Eleonora Colombo, Leonardo Maiorana, Greta Donati, Andrea Menegon, Nicoletta Collura, Luca Muzio, Eloise Mastrangelo, Mario Milani, Luciana Marinelli, Pierfausto Seneci

Abstract readReview
In one paragraph

Review in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eleonora ColomboChemistry Department, Università degli Studi di Milano, Via Golgi 19, 20133 Milan, Italy.
Leonardo MaioranaChemistry Department, Università degli Studi di Milano, Via Golgi 19, 20133 Milan, Italy.
Greta DonatiDepartment of Pharmacy, Università degli Studi di Napoli Federico II, via D. Montesano 49, 80131 Napoli, Italy.
Andrea MenegonExperimental Imaging Centre, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy.
Nicoletta ColluraExperimental Imaging Centre, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy.
Luca MuzioNeuroscience Division, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy.
Eloise MastrangeloInstitute of Biophysics (IBF), CNR, Via Celoria 26, 20133 Milan, Italy.ORCID 0000-0002-5968-8386
Mario MilaniInstitute of Biophysics (IBF), CNR, Via Celoria 26, 20133 Milan, Italy.
Luciana MarinelliDepartment of Pharmacy, Università degli Studi di Napoli Federico II, via D. Montesano 49, 80131 Napoli, Italy.ORCID 0000-0002-4084-8044
Pierfausto SeneciChemistry Department, Università degli Studi di Milano, Via Golgi 19, 20133 Milan, Italy.ORCID 0000-0001-9709-7344

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guanyl hydrazones are emerging as valuable, target-tunable functional groups. In particular, aryl guanyl hydrazones, owing to extensive conjugation with aromatic rings, exhibit lower p

Indexed as

Blood-Brain BarrierDrug DesignHydrazonesAnimalsHumansHydrazonesaryl guanyl hydrazonesBBBbioavailabilityNMRnucleic acid bindingpKarational drug designtautomeric equilibria

Identifiers

PMID40693920
PMCPMC12333022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.