Evidence map›Paper›PMID 40693827›Full record

ArticleUnited European gastroenterology journal2025

Adherence to United European Gastroenterology Guidelines on Diagnosis and Therapy of Immunoglobulin-G4-Related Digestive Disease.

Miroslav Vujasinovic, Marco Lanzillotta, Emma L Culver, Vinciane Rebours, Joost P H Drenth, Milica Stojkovic Lalosevic, Jens Vikse, Natalya Gubergrits, Michael Hirth, Vincenzo Cardinale and 13 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in United European gastroenterology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Bridging the Gap: Guideline Adherence in IgG4-Related Digestive Disease.United European gastroenterology journal · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Miroslav VujasinovicDepartment of Upper Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-6496-295X
Marco LanzillottaUniversità Vita-Salute San Raffaele, Milan, Italy.ORCID https://orcid.org/0000-0002-4522-2921
Emma L CulverTranslational Gastroenterology and Liver Unit, John Radcliffe Hospital, Oxford, UK.ORCID https://orcid.org/0000-0001-9644-8392
Vinciane ReboursPancreatology and Digestive Oncology Department, Beaujon Hospital, Université Paris Cité, Clichy, France.ORCID https://orcid.org/0000-0002-0000-4525
Joost P H DrenthDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0001-8027-3073
Milica Stojkovic LalosevicDepartment of Gastroenterology and Hepatology, Clinical Center Serbia, Belgrade, Serbia.
Jens VikseDepartment of Rheumatology, Stavanger University Hospital, Stavanger, Norway.
Natalya GubergritsMultidisciplinary Clinic Into Sana, Odesa, Ukraine.
Michael HirthDepartment of Medicine II, Medical Faculty at Mannheim, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.ORCID https://orcid.org/0009-0005-2185-2776
Vincenzo CardinaleDivision of Gastroenterology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Rodrigo Vieira MottaTranslational Gastroenterology and Liver Unit, John Radcliffe Hospital, Oxford, UK.
Emanuel Della-TorreUniversità Vita-Salute San Raffaele, Milan, Italy.ORCID https://orcid.org/0000-0002-9192-4270
Nicole SciberrasDepartment of Gastroenterology, Mater Dei Hospital, Valletta, Malta.ORCID https://orcid.org/0000-0003-3357-2841
Marcello MaidaDepartment of Medicine and Surgery, University of Enna "Kore", Enna, Italy.ORCID https://orcid.org/0000-0002-4992-9289
Artemis TrikolaDepartment of Gastroenterology, Athens Naval Hospital, Athens, Greece.
Frank LammertDepartment of Medicine II, Saarland University Medical Center, Homburg, Germany.ORCID https://orcid.org/0000-0003-4450-7201
Clemence DescourvièresPancreatology and Digestive Oncology Department, Beaujon Hospital, Université Paris Cité, Clichy, France.
Cyriel PonsioenDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Jens Brøndum FrøkjærDepartment of Radiology, Aalborg University Hospital, Aalborg, Denmark.ORCID https://orcid.org/0000-0001-8722-0070
Alexander SchneiderDepartment of Medicine II, Medical Faculty at Mannheim, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Domenico AlvaroDivision of Gastroenterology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Gabriele CapursoUniversità Vita-Salute San Raffaele, Milan, Italy.ORCID https://orcid.org/0000-0002-0019-8753
J-Matthias LöhrDepartment of Upper Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-7647-198X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionUnited European Gastroenterology (UEG) Guidelines on immunoglobulin G4 (IgG4)-related digestive disease provides evidence-based recommendations for the diagnosis and management of IgG4-related digestive disease. The aim of this study is to evaluate the adherence to recommendations of this IgG4 guideline across centers in Europe. PATIENTS AND

methodsQuestionnaire-based data related to organ involvement, diagnosis, treatment and follow-up of newly diagnosed patients with IgG4-related digestive diseases over a 3-year period, were collected from 14 centers in 11 European countries.

resultsOne hundred and ninety-nine patients (76% males) were included. Median age at diagnosis was 64 years. Most of the patients had concomitant pancreatic and biliary tree involvement (46%), followed by isolated pancreatic involvement (33.5%), isolated biliary tree involvement (18.5%), esophageal involvement (1.5%) or bowel (0.5%) involvement. Most of the patients (64%) underwent a combination of computed tomography and magnetic resonance imaging at diagnosis. Among the 158 autoimmune pancreatitis patients with or without concomitant bile duct involvement, treatment was performed according to guidelines in 115 patients (73%; moderate adherence). Follow-up assessment was performed between 2 and 4 weeks in 75 patients (47%, partial adherence). Among 37 patients with liver- or biliary tree involvement, 29 patients were treated according to guidelines (78%; full adherence). In the follow-up of patients with isolated liver- or biliary tree involvement, we observed moderate adherence in 21 (57%). Disease monitoring for activity and damage using the IgG4 responder activity index was utilized in only 3/14 centers (poor adherence).

conclusionsIgG4-related digestive disease is restricted to the pancreas and bile ducts in the majority of patients. Even in specialist centers with an interest in IgG4-related digestive disease, UEG guideline treatment adherence was moderate, follow-up at 2-4 weeks was only partial, and monitoring for disease activity was poor. These findings highlight the need for ongoing education and improved adherence to monitoring among healthcare providers.

Indexed as

Autoimmune PancreatitisDigestive System DiseasesGastroenterologyGuideline AdherenceImmunoglobulin GImmunoglobulin G4-Related DiseaseAdultAgedAged, 80 and overEuropeFemaleHumansMaleMiddle AgedPractice Guidelines as TopicSurveys and QuestionnairesImmunoglobulin Gadherenceautoimmune pancreatitisbile ductsguidelineIgG4‐related cholangitisIgG4‐related digestive diseaseimmunoglobulin G4pancreasUnited European Gastroenterology

Identifiers

PMID40693827
PMCPMC12529000

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.