Evidence map›Paper›PMID 40693800›Full record

ArticlemBio2025

Rsp5-mediated ubiquitination of a functional analog of the Rim8 arrestin facilitates Rim pathway activation in

Lukas M du Plooy, Corinna Probst, Matthew E Capobianco, Charles Giamberardino, Claudia A Petrucco, J Andrew Alspaugh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lukas M du PlooyDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Corinna ProbstDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Matthew E CapobiancoDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Charles GiamberardinoDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0001-7813-5616
Claudia A PetruccoDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
J Andrew AlspaughDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-3009-627X

Funding

Rapid production of SARS-CoV-2 molecular clones using CRISPR-based yeast recombineeringR01AI100272 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MADHANI, HITEN D · 2012 to 2025
$11.3M
Coordinated responses to host-derived stresses in C. neoformansR01AI175711 · NIAID · DUKE UNIVERSITY · PI ANDREW ALSPAUGH · 2023 to 2026
$1.5M
Arrestin proteins mediate microbial cellular adaptation and fungal virulenceR21AI153799 · NIAID · DUKE UNIVERSITY · PI ALSPAUGH, ANDREW · 2022 to 2023
$443k
Fulbright U.S. Student ProgramNational Research Foundation UID 120180NIAID NIH HHS R01 AI100272NIAID NIH HHS R01 AI175711NIAID NIH HHS R21 AI153799NIH HHS R01 AI175711NIH HHS R21 AI153799
6 · The paper itself

Abstract

Pathogenic microorganisms use varied cellular processes to adapt to the particular stresses encountered in the infected host. These stresses include rapid alterations in ambient temperature, nutrient availability, and extracellular pH. Fungal pathogens, therefore, rely on the activation of stress response pathways such as the Pal/Rim pathway to adapt to the neutral pH encountered when infecting mammals. While this pathway is conserved among human pathogenic fungi, the proteins required for pH sensing appear to have diverged between different fungal phyla. The opportunistic fungal pathogen

Indexed as

Cryptococcus neoformansEndosomal Sorting Complexes Required for TransportFungal ProteinsUbiquitinationUbiquitin-Protein Ligase ComplexesHydrogen-Ion ConcentrationSignal TransductionVirulenceEndosomal Sorting Complexes Required for TransportFungal ProteinsUbiquitin-Protein Ligase Complexesalkaline pH response pathwayarrestinfungal pathogenesisRim101Rim8Rra2Vps23

Identifiers

PMID40693800
PMCPMC12345238

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.