Evidence map›Paper›PMID 40693726›Full record

ArticleOrganic letters2025

Copper-Dependent Hydroxylation Catalyzed by the DUF3328 Enzyme CctR.

Kaushik Seshadri, Chen-Yu Chiang, Kyle K Nagasawa, Yi Tang

Abstract read
In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Emerging classes of copper enzymes.Current opinion in chemical biology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kaushik SeshadriDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, United States.ORCID 0000-0003-3436-4585
Chen-Yu ChiangDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, United States.
Kyle K NagasawaDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.
Yi TangDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, United States.ORCID 0000-0003-1597-0141

Funding

MIRA: Enzymology and Self-Resistance of Natural Product BiosynthesisR35GM118056 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yi Tang · 2016 to 2026
$6.1M
NIGMS NIH HHS R35 GM118056
6 · The paper itself

Abstract

Enzymes containing domain of unknown function (DUF) 3328 are proposed to catalyze varied reactions in fungal natural product biosynthesis, including halogenation, hydroxylation, oxidative cyclization, etc. However, only two DUF3328 enzymes have been very recently characterized: halogenase ApnU and macrocyclase AprY. We report the biochemical characterization of CctR, a DUF3328 enzyme that catalyzes copper- and oxygen-dependent C(sp

Indexed as

CopperBiocatalysisCatalysisHydroxylationMolecular StructureCopper

Identifiers

PMID40693726
PMCPMC12674691

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.