Evidence map›Paper›PMID 40693719›Full record

ArticleAnnals of clinical and translational neurology2025

Continuous Monitoring of Bladder Dysfunction in People With Multiple Sclerosis: Wearables for the Bladder.

Valerie J Block, Shane Poole, Leah McIntyre, Nikki Sisodia, Chelyn Park, Gabby Joseph, Michelle E Van Kuiken, Anne M Suskind, Riley Bove

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In one paragraph

Article in Annals of clinical and translational neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Valerie J BlockDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0001-6199-5484
Shane PooleDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-3203-151X
Leah McIntyreDepartment of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, California, USA.
Nikki SisodiaDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.ORCID 0009-0006-7270-595X
Chelyn ParkDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.
Gabby JosephDepartment of Radiology, University of California San Francisco, San Francisco, California, USA.
Michelle E Van KuikenDepartment of Urology, University of California San Francisco, San Francisco, California, USA.
Anne M SuskindDepartment of Urology, University of California San Francisco, San Francisco, California, USA.
Riley BoveDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.

Funding

National Multiple Sclerosis Society TA-2006-36695
6 · The paper itself

Abstract

backgroundBladder dysfunction affects over 85% of people with multiple sclerosis (PwMS), yet current assessment methods are limited to periodic in-clinic evaluations or subjective patient reports, failing to capture real-world symptom fluctuations.

objectivesTo evaluate the feasibility and validity of using a novel remote bladder ultrasound device for home monitoring of bladder dysfunction in PwMS, comparing remote measurements with standard clinical assessments.

methodsTwenty-two women with MS participated in this 3-month pilot study. Participants were asked to use the wearable ultrasound device at home for at least 3-5 days a month. Remote device measurements were compared with standard clinical data for post-void residual (rPVR vs. cPVR) and urinary frequency (rFrequency vs. 3-day bladder diary frequency). Agreement between measures was assessed using Bland-Altman analyses and correlation coefficients.

resultsParticipants were middle-aged (mean 51.5 years; SD 9.3) with mild-moderate disability (median EDSS 4.0) and mostly relapsing MS (72.7%). Study retention was high (86.4%; 19/22), with mean device utilization of 14.1 days. Good agreement was seen between rPVR and cPVR (mean difference = 32.1 mL, SD = 38.6; 95% limits of agreement: -43.6, 107.9). The rFrequency measure also demonstrated a strong correlation with patient-reported frequency (ICC = 0.81, Pearson's r = 0.793, p = 0.002). Visualization of remote monitoring data revealed substantial day-to-day variability in bladder symptoms not captured by traditional assessments.

conclusionThis pilot study demonstrates the feasibility and preliminary validity of using wearable ultrasound technology for remote monitoring of bladder dysfunction in PwMS. The ability to capture real-world symptom variations could transform assessment and management approaches, enabling more personalized and responsive care strategies.

Indexed as

Multiple SclerosisUrinary Bladder DiseasesWearable Electronic DevicesAdultFeasibility StudiesFemaleHumansMiddle AgedPilot ProjectsUltrasonographyUrinary Bladderbladder dysfunctiondigital health technologymultiple sclerosisremote monitoringwearables

Identifiers

PMID40693719
PMCPMC12455868

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.