Evidence map›Paper›PMID 40693544›Full record

SynthesisCancer medicine2025

Executive Summary of the American Radium Society Appropriate Use Criteria for the Management of Peritoneal Carcinomatosis From Different Tumor Origins: Systematic Review and Guidelines.

Expert Panel Management of Peritoneal Carcinomatosis, Timothy Kennedy, Sareena Singh, Gerard Abood, Eric Christenson, Christopher J Anker, Dmitriy Akselrod, Christopher L Hallemeier, Krishan R Jethwa, Ed Kim and 9 more

Abstract readSystematic Review
In one paragraph

Synthesis in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Expert Panel Management of Peritoneal Carcinomatosis
Timothy KennedyDepartment of Surgery, Rutgers Cancer Institute, New Brunswick, New Jersey, USA.
Sareena SinghDepartment of Gynecologic Oncology, MetroHealth, Cleveland, Ohio, USA.
Gerard AboodDepartment of Surgery, Loyola University Stritch School of Medicine, Maywood, Illinois, USA.
Eric ChristensonDivision of Medical Oncology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Christopher J AnkerDivision of Radiation Oncology, University of Vermont Larner College of Medicine, Burlington, Vermont, USA.
Dmitriy AkselrodDepartment of Radiology, University of Vermont Larner College of Medicine, Burlington, Vermont, USA.ORCID https://orcid.org/0000-0002-5357-1814
Christopher L HallemeierDepartment of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0002-3598-6709
Krishan R JethwaDepartment of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Ed KimDepartment of Radiation Oncology, University of Washington, Seattle, WA, USA.
Percy LeeDepartment of Radiation Oncology, City of Hope National Medical Center, Los Angeles, California, USA.
Eric D MillerDepartment of Radiation Oncology, James Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Neil B NewmanDepartment of Radiation Oncology, University of Texas San Antonio Health Science Center, San Antonio, Texas, USA.
J Eva SelfridgeDepartment of Medical Oncology, University Hospitals, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Navesh SharmaDepartment of Radiation Oncology, WellSpan Cancer Center, York, Pennsylvania, USA.
William SmallDepartment of Radiation Oncology, Cardinal Bernadin Cancer Center, Loyola University Stritch School of Medicine, Maywood, Illinois, USA.ORCID https://orcid.org/0000-0002-1623-9863
Leila TchelebiDepartment of Radiation Oncology, Donald and Barbara Zucker School of Medicine Hofstra/Northwell, Hempstead, New York, USA.
Vonetta M WilliamsDepartment of Radiation Oncology, Memorial Sloan Kettering, New York, New York, USA.
Suzanne RussoDepartment of Radiation Oncology, MetroHealth, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-4144-4711

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultimodality therapy incorporating a combination of cytoreductive surgery (CRS), intraperitoneal (IP) and systemic therapy continues to evolve for peritoneal carcinomatosis (PC) However, treatment and outcomes vary depending on tumor of origin.

aimsTo develop Appropriate Use Criteria (AUC) guidelines to facilitate treatment decision-making for patients with PC based on available evidence. MATERIALS AND

methodsThe American Radium Society (ARS) multidisciplinary expert panel performed a comprehensive systematic review. Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) methodology was used. These studies were used to inform the expert panel, which then rated the appropriateness of various treatments in seven representative clinical scenarios through a well-established modified Delphi consensus methodology.

resultsTreatment of PC is often treated with a combination of CRS and IP ± systemic chemotherapy but specific recommendations exist for different tumor types and outcomes vary. DISCUSSION: Treatment of PC is complex and varies depending on origin of primary tumor and extent of disease. These AUC assist in patient and treatment selection for different clinical scenarios.

conclusionA summary of recommendations is outlined to guide practitioners on the management of PC from different tumor origins.

Indexed as

Peritoneal NeoplasmsPractice Guidelines as TopicCombined Modality TherapyCytoreduction Surgical ProceduresHumansUnited Statescytoreductive surgeryearly postoperative intraperitoneal chemotherapy (EPIC)hyperthermic intraperitoneal chemotherapy (HIPEC)intraperitonealperitoneal carcinomatosispressurized intraperitoneal aerosolized chemotherapy (PIPAC)

Identifiers

PMID40693544
PMCPMC12281213

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.