Evidence map›Paper›PMID 40693456›Full record

ArticleJournal of chemical information and modeling2025

Dynamic Behavior and Substrate Interactions of the Polymyxin Resistance Determinant MCR-1 Investigated by Molecular Dynamics Simulations in the Membrane Environment.

Emily Lythell, Jack Badley, Reynier Suardíaz, Catherine R Gurr, Catherine L Tooke, Philip Hinchliffe, A Sofia F Oliveira, Marc W Van der Kamp, James Spencer, Adrian J Mulholland

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of chemical information and modeling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emily LythellCentre for Computational Chemistry, School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, U.K.
Jack BadleyCentre for Computational Chemistry, School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, U.K.
Reynier SuardíazCentre for Computational Chemistry, School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, U.K.ORCID 0000-0002-1035-9020
Catherine R GurrSchool of Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol BS8 1TD, U.K.
Catherine L TookeSchool of Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol BS8 1TD, U.K.
Philip HinchliffeSchool of Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol BS8 1TD, U.K.ORCID 0000-0001-8611-4743
A Sofia F OliveiraCentre for Computational Chemistry, School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, U.K.ORCID 0000-0001-8753-4950
Marc W Van der KampSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, U.K.ORCID 0000-0002-8060-3359
James SpencerSchool of Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol BS8 1TD, U.K.ORCID 0000-0002-4602-0571
Adrian J MulhollandCentre for Computational Chemistry, School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, U.K.ORCID 0000-0003-1015-4567

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Mobile Colistin Resistance (MCR) phosphoethanolamine (PEtN) transferase is a plasmid-borne enzyme responsible for colistin antibiotic resistance in

Indexed as

Cell MembraneDrug Resistance, BacterialEscherichia coli ProteinsMolecular Dynamics SimulationPolymyxinsAnti-Bacterial AgentsColistinEscherichia coliEthanolaminesPhosphatidylethanolaminesSubstrate Specificity1-palmitoyl-2-oleoylphosphatidylethanolamineAnti-Bacterial AgentsColistinEscherichia coli ProteinsEthanolaminesMCR-1 protein, E coliPhosphatidylethanolaminesPolymyxins

Identifiers

PMID40693456
PMCPMC12344761

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.