Evidence map›Paper›PMID 40693455›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Integrative Single-Cell Analysis Reveals Iron Overload-Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis-Associated Infertility.

Yangshuo Li, Wei Zhou, Jie Ding, Di Song, Wen Cheng, Jin Yu, Shuai Sun, Shanshan Mei, Xiaolan Liang, Qianqian Zhao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yangshuo LiDepartment of Traditional Chinese Gynecology, the First Affiliated Hospital of Naval Military Medical University, Shanghai, 200433, China.
Wei ZhouBeijing Institute of Radiation Medicine, Beijing, 100850, China.
Jie DingDepartment of Traditional Chinese Gynecology, the First Affiliated Hospital of Naval Military Medical University, Shanghai, 200433, China.
Di SongDepartment of Assisted Reproduction, the First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Wen ChengDepartment of Traditional Chinese Gynecology, the First Affiliated Hospital of Naval Military Medical University, Shanghai, 200433, China.
Jin YuDepartment of Traditional Chinese Gynecology, the First Affiliated Hospital of Naval Military Medical University, Shanghai, 200433, China.
Shuai SunDepartment of Traditional Chinese Gynecology, the First Affiliated Hospital of Naval Military Medical University, Shanghai, 200433, China.
Shanshan MeiDepartment of Gynecology and Obstetrics, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang Province, 310006, China.
Xiaolan LiangDepartment of Traditional Chinese Gynecology, the First Affiliated Hospital of Naval Military Medical University, Shanghai, 200433, China.
Qianqian ZhaoDepartment of Traditional Chinese Gynecology, the First Affiliated Hospital of Naval Military Medical University, Shanghai, 200433, China.
Yanping KuangDepartment of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Mingqing LiDepartment of Reproductive Immunology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China.
Zhexin NiBeijing Institute of Radiation Medicine, Beijing, 100850, China.
Chaoqin YuDepartment of Traditional Chinese Gynecology, the First Affiliated Hospital of Naval Military Medical University, Shanghai, 200433, China.ORCID https://orcid.org/0000-0003-1614-2655
Yue GaoBeijing Institute of Radiation Medicine, Beijing, 100850, China.

Funding

National Natural Science Foundation of China 82074206National Natural Science Foundation of China 82304962National Natural Science Foundation of China 82374503the Young Elite Scientists Sponsorship Program by CAST 2024-2026QNRC001Zhejiang Provincial Natural Science Foundation of China ZCLQN25H2702
6 · The paper itself

Abstract

Endometriosis, particularly ovarian endometriosis (OE), is a major cause of infertility, often associated with reduced oocyte quality and impaired ovarian function. Iron overload plays a key role in OE progression. This study investigates the effects of iron overload on follicular function in OE-associated infertility (OEI). A single-cell atlas of pre-ovulatory follicular fluid from OEI patients reveals dynamic changes in iron metabolism and iron-induced senescence phenotypes. Spatial transcriptomics using Stereo-seq in iron-overloaded mouse ovaries further identifies localized senescence features. Additional analysis of aging human ovaries highlights conserved patterns of iron dysregulation. These findings provide mechanistic insight into iron overload-related ovarian pathology and suggest potential therapeutic targets for improving oocyte quality in OEI.

Indexed as

Cellular SenescenceEndometriosisInfertility, FemaleIron OverloadSingle-Cell AnalysisAdultAnimalsFemaleHumansIronMetabolic ReprogrammingMiceOvaryIronendometriosisinfertilityironmulti‐omicssenescence

Identifiers

PMID40693455
PMCPMC12362736

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.