Evidence map›Paper›PMID 40693440›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Sensory impairment and dementia risk among older adults in rural South Africa.

Muqi Guo, Darina T Bassil, Meagan T Farrell, Ryan G Wagner, Brent Tipping, Nomsa B Mahlalela, David A Kapaon, Stephen Tollman, Lisa F Berkman

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Sensory impairment and dementia risk among older adults in rural South Africa.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Muqi GuoHarvard Center for Population and Development Studies, Harvard University, Cambridge, Massachusetts, USA.
Darina T BassilHarvard Center for Population and Development Studies, Harvard University, Cambridge, Massachusetts, USA.
Meagan T FarrellHarvard Center for Population and Development Studies, Harvard University, Cambridge, Massachusetts, USA.
Ryan G WagnerMRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Mpumalanga, South Africa.
Brent TippingDivision of Geriatric Medicine, Wits Donald Gordon Medical Centre, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg, South Africa.
Nomsa B MahlalelaHealth Economics and Epidemiology Research Office, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg, South Africa.
David A KapaonDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Stephen TollmanMRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Mpumalanga, South Africa.
Lisa F BerkmanHarvard Center for Population and Development Studies, Harvard University, Cambridge, Massachusetts, USA.

Funding

SOCIAL AND ECONOMIC PREDICTORS OF PHYSICAL AND COGNITIVE FUNCTIONP01AG041710 · NIA · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Julia Katherine Rohr · 2013 to 2026
$37.3M
Cognitive Function, Alzheimer's Disease and Related Disorders in the HAALSI CohortR01AG054066 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI BERKMAN, LISA F · 2018 to 2022
$4.6M
NIA NIH HHS P01 AG041710NIA NIH HHS R01 AG054066NIH HHS P01 AG041710U.S. National Institute on Aging
6 · The paper itself

Abstract

introductionSouth Africa faces growing dementia challenges, worsened by limited medical resources and low education. Modifiable risk factors like hearing and vision impairments remain understudied despite their high prevalence.

methodsWe analyzed data from 567 participants in a rural South African cohort to examine the associations between vision and hearing impairment, and dementia outcomes. Multinomial logistic regression assessed associations between sensory impairments (distance vision, near vision, hearing) and mild cognitive impairment (MCI) or dementia. Linear regression examined sensory impairment and predicted dementia probability score 2 years later.

resultsHalf of the participants were over 70, with no formal education. Sensory impairments were common, especially in dementia cases. Distance vision impairment was linked to both MCI and dementia, while near vision and hearing impairments were associated with dementia. Hearing impairment also predicted higher dementia probability after 2 years. DISCUSSION: Addressing sensory impairments is key to dementia prevention in rural South Africa. HIGHLIGHTS: Among rural older South Africans, 65% had near vision impairment and 47% had hearing impairment. Distance or near vision and hearing impairments are linked to an increased risk of dementia. Distance vision impairment is also associated with a higher risk of mild cognitive impairment (MCI). Dementia risk was seven times higher with distance vision, near vision and hearing impairment. Hearing impairment increased the probability of dementia 2 years later in initially non-demented individuals.

Indexed as

Cognitive DysfunctionDementiaHearing LossRural PopulationVision DisordersAgedAged, 80 and overCohort StudiesFemaleHumansMaleMiddle AgedRisk FactorsSouth Africadementiadistance visionhearingnear visionrural South Africasensory impairment

Identifiers

PMID40693440
PMCPMC12281023

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.