Evidence map›Paper›PMID 40693400›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2026

Differences in IgG Sialylation Distinguish Asymptomatic From Symptomatic Antinuclear Antibody-Positive Individuals.

Carolina Muñoz-Grajales, Carmen C Ucciferri, Sindhu R Johnson, Zahi Touma, Zareen Ahmad, Dennisse Bonilla, Linda T Hiraki, Arthur Bookman, Joan E Wither

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis & rheumatology (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carolina Muñoz-GrajalesDepartment of Immunology, Faculty of Medicine, University of Toronto and Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, and Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Carmen C UcciferriDepartment of Immunology, Faculty of Medicine, University of Toronto and Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Sindhu R JohnsonToronto Scleroderma Program, Division of Rheumatology, Toronto Western and Mount Sinai Hospitals and Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-0591-2976
Zahi ToumaDepartment of Medicine, Faculty of Medicine and Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Schroeder Arthritis Institute, University of Toronto, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0001-5177-2076
Zareen AhmadToronto Scleroderma Program, Division of Rheumatology, Toronto Western and Mount Sinai Hospitals and Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Dennisse BonillaSchroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Linda T HirakiDivision of Rheumatology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-6690-8148
Arthur BookmanDepartment of Medicine, Faculty of Medicine, University of Toronto and Division of Rheumatology, Schroeder Arthritis Institute, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0003-4016-8054
Joan E WitherDepartment of Immunology and Department of Medicine, Faculty of Medicine, University of Toronto and Krembil Research Institute and Division of Rheumatology, Schroeder Arthritis Institute, University Health Network, Toronto, Ontario, Canada.

Funding

CIHR FRN 159563
6 · The paper itself

Abstract

objectiveThe transition from asymptomatic antinuclear antibody (ANA) positivity to systemic autoimmune rheumatic disease (SARD) is associated with increased production of proinflammatory factors such as tumor necrosis factor α (TNFα). Here we investigate whether the relative absence of inflammation in asymptomatic ANA

methodsFlow cytometry was used to characterize circulating microparticles (MPs) in 18 healthy controls (ANA

resultsAll ANA

conclusionThe absence of proinflammatory factors in ANA

Indexed as

Antibodies, AntinuclearAutoimmune DiseasesImmunoglobulin GN-Acetylneuraminic AcidRheumatic DiseasesAdultAgedAntigen-Antibody ComplexAsymptomatic DiseasesCase-Control StudiesCell-Derived MicroparticlesDendritic CellsFemaleFlow CytometryHumansLupus Erythematosus, SystemicAntibodies, AntinuclearAntigen-Antibody ComplexImmunoglobulin GN-Acetylneuraminic AcidTumor Necrosis Factor-alpha

Identifiers

PMID40693400
PMCPMC12854008

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.