Evidence map›Paper›PMID 40693399›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

A Promising Point-of-Care Testing Strategy: Ultrasmooth Gold Nanogroove Arrays Biosensor Combined with Initial Rate Analysis.

Yi Liu, Shan Xing, Zhan Si, Kai He, Manchun Zheng, Yang Shen, Chongjun Jin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yi LiuState Key Laboratory of Optoelectronic Materials and Technologies, School of Materials Science and Engineering, Sun Yat-Sen University, No.132, East Outer Ring Road, Guangzhou Higher Education Mega Center, Guangzhou, Guangdong, 510006, China.
Shan XingDepartment of Clinical Laboratory, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, Guangdong, 510060, China.
Zhan SiState Key Laboratory of Optoelectronic Materials and Technologies, School of Materials Science and Engineering, Sun Yat-Sen University, No.132, East Outer Ring Road, Guangzhou Higher Education Mega Center, Guangzhou, Guangdong, 510006, China.
Kai HeState Key Laboratory of Optoelectronic Materials and Technologies, School of Materials Science and Engineering, Sun Yat-Sen University, No.132, East Outer Ring Road, Guangzhou Higher Education Mega Center, Guangzhou, Guangdong, 510006, China.
Manchun ZhengState Key Laboratory of Optoelectronic Materials and Technologies, School of Materials Science and Engineering, Sun Yat-Sen University, No.132, East Outer Ring Road, Guangzhou Higher Education Mega Center, Guangzhou, Guangdong, 510006, China.
Yang ShenState Key Laboratory of Optoelectronic Materials and Technologies, School of Materials Science and Engineering, Sun Yat-Sen University, No.132, East Outer Ring Road, Guangzhou Higher Education Mega Center, Guangzhou, Guangdong, 510006, China.ORCID https://orcid.org/0009-0003-9371-5207
Chongjun JinState Key Laboratory of Optoelectronic Materials and Technologies, School of Materials Science and Engineering, Sun Yat-Sen University, No.132, East Outer Ring Road, Guangzhou Higher Education Mega Center, Guangzhou, Guangdong, 510006, China.ORCID https://orcid.org/0000-0002-9308-5343

Funding

National Natural Science Foundation of China 12274476National Natural Science Foundation of China 12374414National Natural Science Foundation of China 91850106
6 · The paper itself

Abstract

Nowadays, plasmonic biosensors have achieved the limit of detection (LOD) far beyond the clinical or professional standards in the sensing field through material and structural optimizations. However, it remains predominantly a research tool due to the challenge to simultaneously achieve mass production, ultrasensitive and rapid detection, high-reproducibility, and ease of integration, which are extremely desired in point-of-care testing (POCT)-based commercial products. Here, a label-free, ultrasensitive, and rapid assay protocol is described for quantitative protein detections in serum samples, which integrates an ultrasmooth gold nanogroove arrays (UGNA) biosensor with an initial rate analysis (IRA) method. i) Compared with the existing plasmonic biosensors, miscellaneous-protein-mixed scheme substantially accelerates the binding kinetics of analytes by passivation of all channel inner surfaces. Combined with the IRA method, a wide linear range of AFP detection (1-10

Indexed as

Biosensing TechniquesGoldPoint-of-Care TestingHumansLimit of DetectionMetal NanoparticlesPoint-of-Care SystemsReproducibility of ResultsGoldinitial rate analysis (IRA)plasmonic biosensorstumor marker detectionultrasmooth gold nanogroove arrays (UGNA)

Identifiers

PMID40693399
PMCPMC12462996

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.