Evidence map›Paper›PMID 40693376›Full record

ArticleCancer communications (London, England)2025

Lifileucel tumor-infiltrating lymphocyte cell therapy in patients with unresectable or metastatic mucosal melanoma after disease progression on immune checkpoint inhibitors.

Harriet Kluger, Götz Ulrich Grigoleit, Sajeve Thomas, Evidio Domingo-Musibay, Jason A Chesney, Miguel F Sanmamed, Theresa Medina, Mirjana Ziemer, Eric Whitman, Friedrich Graf Finckenstein and 7 more

Registry-linked trialAbstract read
In one paragraph

Article in Cancer communications (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02360579 (A Phase 2, Multicenter Study to Assess the Efficacy and Safety of Autologous Tumor Infiltrating Lymphocytes), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02360579 phase2completednot on this map

A Phase 2, Multicenter Study to Assess the Efficacy and Safety of Autologous Tumor Infiltrating Lymphocytes (LN-144) for Treatment of Patients With Metastatic Melanoma

TypeinterventionalSponsorIovance Biotherapeutics, Inc.Ran2015 to 2024Enrolled220ConditionsMetastatic MelanomaArmsLifileucel
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Harriet KlugerYale Cancer Center, New Haven, Connecticut, USA.
Götz Ulrich GrigoleitHelios Klinikum Duisburg, Duisburg, Germany.
Sajeve ThomasAdventHealth Cancer Institute, Orlando, Florida, USA.
Evidio Domingo-MusibayDivision of Hematology, Oncology, and Transplantation, Masonic Cancer Center, Minneapolis, Minnesota, USA.
Jason A ChesneyDivision of Medical Oncology and Hematology, Brown Cancer Center, Louisville, Kentucky, USA.
Miguel F SanmamedUniversity of Navarra Clinic, Pamplona, Navarra, Spain.
Theresa MedinaMedical Oncology, University of Colorado Cancer Center, Aurora, Colorado, USA.
Mirjana ZiemerUniversity Hospital Leipzig, Leipzig, Germany.
Eric WhitmanAtlantic Melanoma Center, Atlantic Health System, Morristown, New Jersey, USA.
Friedrich Graf FinckensteinIovance Biotherapeutics, Inc., San Carlos, California, USA.
Brian GastmanIovance Biotherapeutics, Inc., San Carlos, California, USA.
Jeffrey ChouIovance Biotherapeutics, Inc., San Carlos, California, USA.
Xiao WuIovance Biotherapeutics, Inc., San Carlos, California, USA.
Giri SulurIovance Biotherapeutics, Inc., San Carlos, California, USA.
Rana FiazIovance Biotherapeutics, Inc., San Carlos, California, USA.
Rongsu QiIovance Biotherapeutics, Inc., San Carlos, California, USA.
Amod A SarnaikCutaneous Oncology and Immunology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.ORCID https://orcid.org/0000-0002-2337-5898

Funding

Iovance Biotherapeutics, Inc.
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40693376
PMCPMC12531414

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.