Evidence map›Paper›PMID 40693363›Full record

ArticleMagnetic resonance in medicine2025

Evaluation of renal masses with CEST MRI: Protocol optimization and preliminary results.

Xiaojing Wang, Jochen Keupp, Ivan E Dimitrov, Ananth Madhuranthakam, Durga Udayakumar, Mahsa Taherzadeh, Emin Albayrak, Orson W Moe, Payal Kapur, Robert E Lenkinski and 2 more

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaojing WangDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jochen KeuppPhilips Innovative Technologies, Hamburg, Germany.
Ivan E DimitrovPhilips, Cambridge, Massachusetts, USA.
Ananth MadhuranthakamDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID https://orcid.org/0000-0002-5524-7962
Durga UdayakumarDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID https://orcid.org/0000-0002-8867-2869
Mahsa TaherzadehDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Emin AlbayrakDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Orson W MoeDepartment of Internal Medicine and Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Payal KapurDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Robert E LenkinskiDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ivan PedrosaDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Elena VinogradovDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID https://orcid.org/0000-0003-4607-4147

Funding

NON-INVASIVE PHYSIOLOGIC PREDICTORS OF AGGRESSIVENESS IN RENAL CELL CARCINOMAR01CA154475 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI PEDROSA, IVAN · 2011 to 2024
$4.3M
Chemical Exchange Saturation Transfer (CEST) MRI for the Characterization Small Renal MassesR01CA252281 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI PEDROSA, IVAN, VINOGRADOV, ELENA · 2021 to 2025
$2.1M
Endogenous Urea CEST MRI (urCEST): pH and urea gradient mapping in human kidneyR21EB020245 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI VINOGRADOV, ELENA · 2016 to 2017
$445k
NCI NIH HHS R01 CA154475NCI NIH HHS R01 CA252281NIBIB NIH HHS R21 EB020245NIH HHS R01CA154475NIH HHS R01CA252281NIH HHS R21EB020245
6 · The paper itself

Abstract

purposeThis study investigates the application of CEST MRI in human kidneys, with the overarching goal of developing CEST MRI for renal mass characterization. Here, the focus is on the development of a protocol and the proof-of-principle evaluation of CEST for the characterization of clear cell renal cell carcinoma (ccRCC).

methodsTen healthy volunteers and five patients diagnosed with ccRCC underwent CEST MRI scans at 3 T. The sequence performance was characterized in healthy volunteers and tested using three saturation power levels, B

resultsSignificant differences in MTR

conclusionCEST MRI demonstrates considerable potential as a non-invasive imaging tool for the characterization of renal masses.

Indexed as

Carcinoma, Renal CellKidneyKidney NeoplasmsMagnetic Resonance ImagingAdultAgedFemaleHealthy VolunteersHumansImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedMaleMiddle Aged

Identifiers

PMID40693363
PMCPMC12501682

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.