Evidence map›Paper›PMID 40693357›Full record

ArticleMagnetic resonance in medicine2025

Surgical removal of implanted microchips to correct MRI susceptibility artifacts in mice.

Elizabeth Hipskind, Nicole Hernandez, Sydney Fox, Tina Manirambona, Rita Schack, Brian Gibson, Robia G Pautler

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elizabeth HipskindDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas, USA.
Nicole HernandezCenter for Comparative Medicine, Baylor College of Medicine, Houston, Texas, USA.
Sydney FoxDepartment of Integrative Physiology, Baylor College of Medicine, Houston, Texas, USA.
Tina ManirambonaDepartment of Integrative Physiology, Baylor College of Medicine, Houston, Texas, USA.
Rita SchackDepartment of Integrative Physiology, Baylor College of Medicine, Houston, Texas, USA.
Brian GibsonCenter for Comparative Medicine, Baylor College of Medicine, Houston, Texas, USA.
Robia G PautlerDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas, USA.ORCID https://orcid.org/0000-0001-7952-8526

Funding

Incorporating Spatial Proteomics to Understand the Basis of Hyper and Hypoconnectivity in mouse models of ADR01AG081192 · NIA · BAYLOR COLLEGE OF MEDICINE · PI ROBIA G PAUTLER, Md. Abul Hassan Samee · 2024 to 2026
$2.3M
National Institutes of Health (NIH)/National Institute of Aging (NIA) R01AG081192NIA NIH HHS R01 AG081192
6 · The paper itself

Abstract

purposeImplanted microchips are becoming increasingly common in research for animal identification and have been adopted by commercial vendors for some mouse strains. However, they often contain metal components, which generate magnetic susceptibility artifacts on MR images. Despite this, some microchips are marketed as MR-compatible, even though they are likely to affect image quality.

methodsWe assessed the impact of a radiofrequency identification microchip on MR images of the mouse brain and present a method for precise surgical removal. A handheld magnet was used to locate and stabilize the microchips during removal. Mice were imaged before and after microchip removal.

resultsAlthough marketed as MR-compatible, implanted microchips caused magnetic susceptibility artifacts in all imaged mice, despite variation in the location of the microchip. Surgical removal corrected these artifacts, allowing for high-resolution imaging without interference. All subjects recovered well from the procedure.

conclusionThe discrepancy in the use of the term "MR-compatible" highlights a disconnect between researchers and some manufacturers. Microchips should be carefully evaluated for experiments involving MRI. In the event that microchips require removal before imaging, surgical removal using a handheld magnet to precisely locate the microchips is effective.

Indexed as

Animal Identification SystemsArtifactsBrainDevice RemovalMagnetic Resonance ImagingProstheses and ImplantsAnimalsMiceMice, Inbred C57BLReproducibility of ResultsSensitivity and SpecificitymicemicrochipMRIpreclinical modelsurgical removalsusceptibility artifact

Identifiers

PMID40693357
PMCPMC12501651

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.