Evidence map›Paper›PMID 40693314›Full record

ArticleAdvanced healthcare materials2025

Ionic Liquid-Mediated Delivery of Ruxolitinib to Skin Using an Adhesive Topical Hydrogel System.

Nicole B Day, Christopher R Orear, Alysha N Hunter, Matthew M C Kwan, Christine M Hamadani, Ava d'Auvergne, Junling Guo, Eden E L Tanner, C Wyatt Shields

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nicole B DayDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.ORCID 0000-0003-1082-2887
Christopher R OrearBiomedical Engineering Program, University of Colorado Boulder, Boulder, CO, 80303, USA.
Alysha N HunterDepartment of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, 38677, USA.ORCID 0009-0003-6897-4872
Matthew M C KwanMaterials Science & Engineering Program, University of Colorado Boulder, Boulder, CO, 80303, USA.ORCID 0009-0007-6606-5113
Christine M HamadaniDepartment of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, 38677, USA.ORCID 0000-0003-4774-6777
Ava d'AuvergneDepartment of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, 38677, USA.
Junling GuoBMI Center for Biomass Materials and Nanointerfaces, National Engineering Laboratory for Clean Technology of Leather Manufacture, Ministry of Education (MOE) Key Laboratory of Leather Chemistry and Engineering, and College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan, 610065, China.ORCID 0000-0002-2948-880X
Eden E L TannerDepartment of Chemistry and Biochemistry, University of Mississippi, Oxford, MS, 38677, USA.ORCID 0000-0002-7919-2249
C Wyatt ShieldsDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.ORCID 0000-0003-4138-8462

Funding

Predoctoral Training Molecular BiophysicsT32GM065103 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI FALKE, JOSEPH J · 2002 to 2021
$4.3M
Mechanisms of p27Kipl Proteolysis in Cancer CellsR01CA107098 · NCI · UNIVERSITY OF COLORADO AT BOULDER · PI LIU, XUEDONG · 2004 to 2012
$2.7M
Interdisciplinary Predoctoral Training in Molecular BiophysicsT32GM145437 · NIGMS · UNIVERSITY OF COLORADO · PI JOSEPH J FALKE · 2022 to 2026
$2.5M
FACSAria Fusion Cell SorterS10OD021601 · OD · UNIVERSITY OF COLORADO · PI LIU, XUEDONG · 2016 to 2016
$599k
G-RISE at The University of MississippiT32GM144924 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI BARNARD, MARIE, MAJUMDAR, SOUMYAJIT · 2024 to 2024
$179k
National Institutes of Health (NIH) T32GM144924NCI NIH HHS R01 CA107098NIGMS NIH HHS T32 GM065103NIGMS NIH HHS T32 GM144924NIGMS NIH HHS T32 GM145437NIH HHS S10 OD021601
6 · The paper itself

Abstract

Delivery of many drug types to the skin is prohibited by the stratum corneum, and drugs that can penetrate the epidermal barrier (e.g., small, nonpolar molecules) often have limited permeation in the dermis. Ionic liquids (ILs) are well-known penetration enhancers, yet, achieving sustained, controlled drug release from ILs alone remains a significant challenge. Herein, ILs are incorporated into a removable, phenolic-functionalized tissue-adhesive hydrogel system for the treatment of atopic dermatitis. The hydrogel, enriched with galloyl groups from plant polyphenols, provides robust skin adhesion, effectively securing IL and ruxolitinib (Janus kinase (JAK) 1/2 inhibitor)-loaded nanoparticles at the target site and enabling sustained delivery of the IL-carried ruxolitinib into the dermis. The IL choline trans-2-butenoic acid (CA2BE) 1:1 can be embedded within the adhesive hydrogel without compromising its mechanical properties or inflaming macrophages. Importantly, the IL-mediated transport of drug into the skin causes a significant increase in ruxolitinib accumulation within the dermis, surpassing that of a clinical ointment analog. By combining efficient skin permeation, controlled release, and strong adhesion, this multifunctional platform offers significant potential for topical drug delivery across a range of skin disorders, extending beyond atopic dermatitis.

Indexed as

Drug Delivery SystemsHydrogelsIonic LiquidsPyrazolesSkinAdministration, CutaneousAnimalsDermatitis, AtopicHumansMiceNanoparticlesNitrilesPyrimidinesHydrogelsIonic LiquidsNitrilesPyrazolesPyrimidinesruxolitinibcontrolled releasedrug deliveryhydrogelsionic liquidsphenol

Identifiers

PMID40693314
PMCPMC13173415

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.