ArticleFrontiers in cardiovascular medicine2025
Endoplasmic reticulum stress of astrocytes in paraventricular nucleus of hypothalamus promotes ventricular electrical instability after acute myocardial infarction in rats.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Endoplasmic reticulum stress and unfolded protein response in immune cell function.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Astrocytes in paraventricular nucleus of hypothalamus (PVN) promote the occurrence of ventricular arrhythmia (VA) after acute myocardial infarction (AMI). However, the mechanism is unclear. The purpose of this study was to investigate the changes of astrocytes in the PVN after AMI, which is involved in ventricular electrical instability in rats. Methods: The rats were randomly divided into 4 groups: sham operation (SH), AMI, AMI + Vehicle (4 μl for each), AMI + GSK2606414(PERK phosphorylation inhibitor, 90 μg/4 μl for each). PVN was administered by microinjection. Results: After 24 h, the AMI and AMI + Vehicle groups had substantially greater levels of hypothalamic astrocyte activation, endoplasmic reticulum (ER) stress, and central inflammation (TNF-α and IL-6) compared to the SH group ( Conclusion: As a result, 24 h after AMI, PVN astrocytes underwent ER stress via PERK/CHOP pathway, which caused central inflammation, sympathetic neuron activation, and increased ventricular electrical activity instability. GSK2606414 microinjection into hypothalamus decreased sympathetic nerve excitement and VA occurrence in AMI rats by inhibiting ER stress of PVN astrocytes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.